Email this article THE SONOGRAPHIC DYNAMICS OF PERIPHERAL NERVES CROSS SECTIONAL AREA CHANGES IN MULTIFOCAL MOTOR NEUROPATHY TREATED WITH INTRAVENOUS IMMUNOGLOBULIN: CASE REPORT
- Authors: Nikitin S.S.1, Naumova E.S.1, Druzhinin D.S.2
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Affiliations:
- Association of Neuromuscular Disorders Specialists, Medical Center “Practical Neurology”
- Department of Neurological Diseases with a Course of Medical Genetics and Pediatric Neurology, Yaroslavl’ State Medical University
- Issue: Vol 6, No 4 (2016)
- Pages: 46-51
- Section: CLINICAL DISCUSSION
- Published: 04.01.2017
- URL: https://nmb.abvpress.ru/jour/article/view/179
- DOI: https://doi.org/10.17650/2222-8721-2016-6-4-46-51
- ID: 179
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Abstract
Background. Multifocal motor neuropathy (MMN) is а chronical dysimmune disease, which can be treated with intravenous human immunoglobulin (IVIG).
Objectives. To follow up the sonographic changes of peripheral nerves in a patient with MMN treated with IVIG.
Materials and methods. A 42 y.o. woman with MMN receiving IVIG is described. The cross-sectional area (CSA) of median, ulnar nerves and spinal roots was measured with high-resolution ultrasound (HRUS) after five IVIG courses.
Results. Before treatment the asymmetrical CSA increase of median, ulnar nerves and C5, C6, C7 spinal roots was found. 7 weeks after the first IVIG, next 3 IVIG courses with 4 weeks’ intervals HRUS showed normalization of CSA of the peripheral nerves and significant decrease of CSA of the spinal roots; as soon as the interval between the fourth and fifth IVIG was prolonged up to 9 weeks the CSA of the peripheral nerves increased again.
Conclusion. The follow up of a MMN patient treated with IVIG confirms the positive sonographic changes of the peripheral nerves and spinal roots. The possible role of HRUS as a method for monitoring changes in the peripheral nerves due to IVIG should be discussed after a larger cohort of patients with MMN and similar diseases is investigated.
About the authors
S. S. Nikitin
Association of Neuromuscular Disorders Specialists, Medical Center “Practical Neurology”
Author for correspondence.
Email: nikitin-s@bk.ru
Build. 2, 17 Krzhizhanovskogo St., Moscow 117258
Russian FederationE. S. Naumova
Association of Neuromuscular Disorders Specialists, Medical Center “Practical Neurology”
Email: fake@neicon.ru
Build. 2, 17 Krzhizhanovskogo St., Moscow 117258
Russian FederationD. S. Druzhinin
Department of Neurological Diseases with a Course of Medical Genetics and Pediatric Neurology, Yaroslavl’ State Medical University
Email: fake@neicon.ru
25 Revolutsionnaya St., Yaroslavl’ 150000
Russian FederationReferences
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