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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Neuromuscular Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Neuromuscular Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Нервно-мышечные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-8721</issn><issn publication-format="electronic">2413-0443</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">121</article-id><article-id pub-id-type="doi">10.17650/2222-8721-2015-5-3-31-36</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURES AND REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИИ И ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Practical issues of management of patients with chronic migraine. Recommendations from Russian experts</article-title><trans-title-group xml:lang="ru"><trans-title>Практические вопросы ведения пациентов с хронической мигренью. Рекомендации российских экспертов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Latysheva</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Латышева</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ninalat@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Filatova</surname><given-names>E. G.</given-names></name><name xml:lang="ru"><surname>Филатова</surname><given-names>Е. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tabeeva</surname><given-names>G. R.</given-names></name><name xml:lang="ru"><surname>Табеева</surname><given-names>Г. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Osipova</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Осипова</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Artemenko</surname><given-names>A. R.</given-names></name><name xml:lang="ru"><surname>Артеменко</surname><given-names>А. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tarasova</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Тарасова</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff5"/><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Azimova</surname><given-names>Y. E.</given-names></name><name xml:lang="ru"><surname>Азимова</surname><given-names>Ю. Э.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff7"/><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Katsarava</surname><given-names>Z.</given-names></name><name xml:lang="ru"><surname>Кацарава</surname><given-names>З.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff9"/><xref ref-type="aff" rid="aff10"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">SBEI HPE “I.M. Sechenov First Moscow State Medical University” of the Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">4 bldg, 2 B. Pirogovskaya St., Moscow, 119991, Russia&#13;
&#13;
Alexander Vein’s Headache Clinic</institution></aff><aff><institution xml:lang="ru">Россия, 119991, Москва, ул. Б. Пироговская, 2, стр. 4&#13;
&#13;
Клиника головной боли академика Александра Вейна</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">10b Staropetrovsky proezd, Moscow, 125130, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 125130, Москва, Старопетровский пр-д, 10б</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">4 bldg, 2 B. Pirogovskaya St., Moscow, 119991, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 119991, Москва, ул. Б. Пироговская, 2, стр. 4</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">V.D. Seredavin Samara Regional Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Самарская областная клиническая больница им. В. Д. Середавина</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">159 Tashkentskaya St., Samara, 443095, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 443095, Самара, ул. Ташкентская, 159</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">University Headache Clinic</institution></aff><aff><institution xml:lang="ru">Университетская клиника головной боли</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">3 Bldg, 17 Protopopovsky per., Moscow, 129090, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 129090, Москва, Протопоповский пер., 17, стр. 3</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="en">Department of Neurology, Unna Evangelic Hospital</institution></aff><aff><institution xml:lang="ru">отделение неврологии Евангелической больницы г. Унна</institution></aff></aff-alternatives><aff-alternatives id="aff10"><aff><institution xml:lang="en">10 Holbeinstrasse, Unna, 59423, Germany</institution></aff><aff><institution xml:lang="ru">Германия, 59423, Унна, Holbeinstrasse, 10</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-09-21" publication-format="electronic"><day>21</day><month>09</month><year>2015</year></pub-date><volume>5</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>31</fpage><lpage>36</lpage><history><date date-type="received" iso-8601-date="2015-09-21"><day>21</day><month>09</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-09-21"><day>21</day><month>09</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Latysheva N.V., Filatova E.G., Tabeeva G.R., Osipova V.V., Artemenko A.R., Tarasova S.V., Azimova Y.E., Katsarava Z.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Латышева Н.В., Филатова Е.Г., Табеева Г.Р., Осипова В.В., Артеменко А.Р., Тарасова С.В., Азимова Ю.Э., Кацарава З.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Latysheva N.V., Filatova E.G., Tabeeva G.R., Osipova V.V., Artemenko A.R., Tarasova S.V., Azimova Y.E., Katsarava Z.</copyright-holder><copyright-holder xml:lang="ru">Латышева Н.В., Филатова Е.Г., Табеева Г.Р., Осипова В.В., Артеменко А.Р., Тарасова С.В., Азимова Ю.Э., Кацарава З.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://nmb.abvpress.ru/jour/article/view/121">https://nmb.abvpress.ru/jour/article/view/121</self-uri><abstract xml:lang="en"><p>The world medicine has achieved considerable advances over the last years in understanding of causes and pathogenesis as well as in specification of diagnostics criteria and studies of therapeutic approaches at chronic migraine (CM). Meantime this widespread disease is badly recognized by the physicians and diagnosed seldom. In addition, there is no generally accepted document, regulating the treatment of patients with CM, who are peculiar by their express deadaptation due to high frequency of severe attacks of the headache (HA), co-morbid psychic and somatic disorders, frequent abuse of analgetic drugs and low adherence to preventive therapy. The specialists of our country, like in other countries, gained their own unique expertise in management of such patients, who are hard to cure, including by botulinum A toxin – representative of the state-of-the-art generation of the registered drugs with the proven efficiency against CM. The article sets out the Recommendation from the Russian specialists as to management of the patients with CM, approved by the meeting of CM Expert Board (on November 12, 2014, Moscow), including with respect to time of treatment, rules of withdrawal and replacement of drugs and some other features, in compliance with modern world concepts on pathogenesis and treatment of such disease and expertise gained in managing patientswith CM in our country.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>chronic migraine</kwd><kwd>refractory migraine</kwd><kwd>preventive treatment</kwd><kwd>botulinum A toxin</kwd><kwd>recommendations from Russian experts</kwd><kwd>Botox</kwd><kwd>medically induced pain</kwd><kwd>detoxication</kwd><kwd>diagnostics</kwd><kwd>treatment rules</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хроническая мигрень</kwd><kwd>рефрактерная мигрень</kwd><kwd>профилактическое лечение</kwd><kwd>ботулинический токсин типа А</kwd><kwd>рекомендации российских экспертов</kwd><kwd>Ботокс</kwd><kwd>лекарственно-индуцированная головная боль</kwd><kwd>детоксикация</kwd><kwd>диагностика</kwd><kwd>правила лечения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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