Neuromuscular DiseasesNeuromuscular DiseasesНервно-мышечные болезни2222-87212413-0443Publishing House ABV Press17810.17650/2222-8721-2016-6-4-37-45CLINICAL CASEКЛИНИЧЕСКИЙ РАЗБОРCHRONIC INTOXICATION WITH “LAUGHING GAS” (NITROUS OXIDE) AS A CAUSE OF B12 DEFICIENCY MYELOPOLYNEUROPATHY IN YOUNG ADULTSХРОНИЧЕСКАЯ ИНТОКСИКАЦИЯ «ВЕСЕЛЯЩИМ ГАЗОМ» (ЗАКИСЬЮ АЗОТА) – ПРИЧИНА В12 -ДЕФИЦИТНОЙ МИЕЛОПОЛИНЕЙРОПАТИИ У ЛИЦ МОЛОДОГО ВОЗРАСТАSuponevaN. A.СупоневаН. А.
Russian Federation

80 Volokolamskoe Shosse, Моscow 125367

125367 Москва, Волоколамское шоссе, 80

GrishinaD. A.ГришинаД. А.
Russian Federation

80 Volokolamskoe Shosse, Моscow 125367

Дарья Александровна Гришина.

125367 Москва, Волоколамское шоссе, 80; DGrishina82@gmail.com

DGrishina82@gmail.comLegostaevaL. A.ЛегостаеваЛ. А.
Russian Federation

80 Volokolamskoe Shosse, Моscow 125367

125367 Москва, Волоколамское шоссе, 80

MochalovaE. G.МочаловаЕ. Г.
Russian Federation

80 Volokolamskoe Shosse, Моscow 125367

125367 Москва, Волоколамское шоссе, 80

Research Center of NeurologyНаучный центр неврологии040120176437450401201704012017Copyright ©; 2017, Suponeva N.A., Grishina D.A., Legostaeva L.A., Mochalova E.G.Copyright ©; 2017, Супонева Н.А., Гришина Д.А., Легостаева Л.А., Мочалова Е.Г.2017Suponeva N.A., Grishina D.A., Legostaeva L.A., Mochalova E.G.Супонева Н.А., Гришина Д.А., Легостаева Л.А., Мочалова Е.Г.https://creativecommons.org/licenses/by/4.0https://nmb.abvpress.ru/jour/article/view/178

The problem of using nitrous oxide (“laughing gas”) is now important because young people often prefer this kind of entertainment. Regular short-term inhalation of nitrous oxide increases the risk of developing vitamin B12 deficiency, which is an essential cofactor of important  metabolic processes. This article describes 2 clinical cases of neurological disorders in young adults who had used nitrous oxide. We demonstrate difficulties in the diagnosis, therapeutic tactics and prognosis. 

В настоящее время проблема злоупотребления закисью азота («веселящим газом») приобрела актуальность, так как среди лиц молодого возраста выросла популярность данного вида «развлечения». Регулярное даже краткосрочное вдыхание закиси азота  повышает вероятность развития дефицита витамина В12 – незаменимого кофактора важных процессов метаболизма. В статье приводятся 2 клинических наблюдения развития неврологических нарушений у молодых людей, злоупотребляющих закисью азота.

Рассмотрены трудности диагностики подобных состояний, терапевтическая тактика и прогноз. 

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