Build. 2, 17 Krzhizhanovskogo St., Moscow 117258
Сергей Сергеевич Никитин.
117258 Москва, ул. Кржижановского, 17/2;
Build. 2, 17 Krzhizhanovskogo St., Moscow 117258
117258 Москва, ул. Кржижановского, 17/2
25 Revolutsionnaya St., Yaroslavl’ 150000
Кафедра нервных болезней с курсом медицинской генетики и детской неврологии.
150000 Ярославль, ул. Революционная, 5
Background. Multifocal motor neuropathy (MMN) is а chronical dysimmune disease, which can be treated with intravenous human immunoglobulin (IVIG).
Objectives. To follow up the sonographic changes of peripheral nerves in a patient with MMN treated with IVIG.
Materials and methods. A 42 y.o. woman with MMN receiving IVIG is described. The cross-sectional area (CSA) of median, ulnar nerves and spinal roots was measured with high-resolution ultrasound (HRUS) after five IVIG courses.
Results. Before treatment the asymmetrical CSA increase of median, ulnar nerves and C5, C6, C7 spinal roots was found. 7 weeks after the first IVIG, next 3 IVIG courses with 4 weeks’ intervals HRUS showed normalization of CSA of the peripheral nerves and significant decrease of CSA of the spinal roots; as soon as the interval between the fourth and fifth IVIG was prolonged up to 9 weeks the CSA of the peripheral nerves increased again.
Conclusion. The follow up of a MMN patient treated with IVIG confirms the positive sonographic changes of the peripheral nerves and spinal roots. The possible role of HRUS as a method for monitoring changes in the peripheral nerves due to IVIG should be discussed after a larger cohort of patients with MMN and similar diseases is investigated.