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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Neuromuscular Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Neuromuscular Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Нервно-мышечные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-8721</issn><issn publication-format="electronic">2413-0443</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">281</article-id><article-id pub-id-type="doi">10.17650/2222-8721-2018-8-2-33-41</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Evaluation of methylation status of the 5’-promoter region of C9orf72 gene in Russian patients with neurodegenerative diseases</article-title><trans-title-group xml:lang="ru"><trans-title>Оценка метилирования 5’-промоторной области гена C9orf72 у российских пациентов с нейродегенеративными заболеваниями</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7214-583X</contrib-id><name-alternatives><name xml:lang="en"><surname>Shpilyukova</surname><given-names>Yu. A.</given-names></name><name xml:lang="ru"><surname>Шпилюкова</surname><given-names>Ю. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>80 Volokolamskoe Shosse, Моscow 125367</italic></p></bio><bio xml:lang="ru"><p><bold>Юлия Александровна Шпилюкова</bold></p><p><italic>125367 Москва, Волоколамское шоссе, 80</italic></p></bio><email>jshpilyukova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedotova</surname><given-names>E. Yu.</given-names></name><name xml:lang="ru"><surname>Федотова</surname><given-names>Е. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>80 Volokolamskoe Shosse, Моscow 125367</italic></p></bio><bio xml:lang="ru"><p><italic>125367 Москва, Волоколамское шоссе, 80</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pogoda</surname><given-names>T. V.</given-names></name><name xml:lang="ru"><surname>Погода</surname><given-names>Т. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>80 Volokolamskoe Shosse, Моscow 125367</italic></p></bio><bio xml:lang="ru"><p><italic>125367 Москва, Волоколамское шоссе, 80</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9419-1159</contrib-id><name-alternatives><name xml:lang="en"><surname>Abramycheva</surname><given-names>N. Yu.</given-names></name><name xml:lang="ru"><surname>Абрамычева</surname><given-names>Н. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>80 Volokolamskoe Shosse, Моscow 125367</italic></p></bio><bio xml:lang="ru"><p><italic>125367 Москва, Волоколамское шоссе, 80</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vetchinova</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Ветчинова</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>80 Volokolamskoe Shosse, Моscow 125367</italic></p></bio><bio xml:lang="ru"><p><italic>125367 Москва, Волоколамское шоссе, 80</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zakharova</surname><given-names>M. N.</given-names></name><name xml:lang="ru"><surname>Захарова</surname><given-names>М. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>80 Volokolamskoe Shosse, Моscow 125367</italic></p></bio><bio xml:lang="ru"><p><italic>125367 Москва, Волоколамское шоссе, 80</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2704-6282</contrib-id><name-alternatives><name xml:lang="en"><surname>Illarioshkin</surname><given-names>S. N.</given-names></name><name xml:lang="ru"><surname>Иллариошкин</surname><given-names>С. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>80 Volokolamskoe Shosse, Моscow 125367</italic></p></bio><bio xml:lang="ru"><p><italic>125367 Москва, Волоколамское шоссе, 80</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Center of Neurology</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Научный центр неврологии»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-07-20" publication-format="electronic"><day>20</day><month>07</month><year>2018</year></pub-date><volume>8</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>33</fpage><lpage>41</lpage><history><date date-type="received" iso-8601-date="2018-07-20"><day>20</day><month>07</month><year>2018</year></date><date date-type="accepted" iso-8601-date="2018-07-20"><day>20</day><month>07</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Shpilyukova Y.A., Fedotova E.Y., Pogoda T.V., Abramycheva N.Y., Vetchinova A.S., Zakharova M.N., Illarioshkin S.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Шпилюкова Ю.А., Федотова Е.Ю., Погода Т.В., Абрамычева Н.Ю., Ветчинова А.С., Захарова М.Н., Иллариошкин С.Н.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Shpilyukova Y.A., Fedotova E.Y., Pogoda T.V., Abramycheva N.Y., Vetchinova A.S., Zakharova M.N., Illarioshkin S.N.</copyright-holder><copyright-holder xml:lang="ru">Шпилюкова Ю.А., Федотова Е.Ю., Погода Т.В., Абрамычева Н.Ю., Ветчинова А.С., Захарова М.Н., Иллариошкин С.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://nmb.abvpress.ru/jour/article/view/281">https://nmb.abvpress.ru/jour/article/view/281</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>amyotrophic lateral sclerosis</kwd><kwd>frontotemporal dementia</kwd><kwd>Parkinson’s disease</kwd><kwd>neurodegenerative diseases</kwd><kwd>C9orf72 gene</kwd><kwd>methylation status of the 5’-promoter region of C9orf72 gene</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>боковой амиотрофический склероз</kwd><kwd>лобно-височная деменция</kwd><kwd>болезнь Паркинсона</kwd><kwd>нейродегенеративные заболевания</kwd><kwd>ген C9orf72</kwd><kwd>метилирование промоторной области гена C9orf72</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1.	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