Neuromuscular DiseasesNeuromuscular DiseasesНервно-мышечные болезни2222-87212413-0443Publishing House ABV Press29210.17650/2222-8721-2018-8-3-34-42ORIGINAL REPORTSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯChronic pain, depression and cognitive impairment: a close relationshipХроническая боль, депрессия и когнитивные нарушения: тесные взаимосвязиhttps://orcid.org/0000-0001-9600-5540LatyshevaN. V.ЛатышеваН. В.
Russian Federation

Build. 2, 8 Trubetskaya St., Moscow 119991; 10b Staropetrovskiy Proezd, Moscow 125130.

119991 Москва, ул. Трубецкая, 8, стр. 2; 

125130 Москва, Старопетровский проезд, 10б.

https://orcid.org/0000-0001-9978-4180FilatovaE. G.ФилатоваЕ. Г.
Russian Federation

Build. 2, 8 Trubetskaya St., Moscow 119991; 10b Staropetrovskiy Proezd, Moscow 125130.

119991 Москва, ул. Трубецкая, 8, стр. 2; 

125130 Москва, Старопетровский проезд, 10б.

OsipovaD. V.ОсиповаД. В.
Russian Federation

Build. 2, 8 Trubetskaya St., Moscow 119991.

119991 Москва, ул. Трубецкая, 8, стр. 2.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииAlexander Vein Headache Clinic.Клиника головной боли и вегетативных расстройств им. акад. Александра Вейна.I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России.261020188334422510201825102018Copyright ©; 2018, Latysheva N.V., Filatova E.G., Osipova D.V.Copyright ©; 2018, Латышева Н.В., Филатова Е.Г., Осипова Д.В.2018Latysheva N.V., Filatova E.G., Osipova D.V.Латышева Н.В., Филатова Е.Г., Осипова Д.В.https://creativecommons.org/licenses/by/4.0https://nmb.abvpress.ru/jour/article/view/292

Over a half of chronic pain (CP) patients present with cognitive complaints, which increase their disability and impact quality of life. The paper reviews objective impairments in memory, attention, processing speed and executive function demonstrated in the CP population. The paper also reviews common pathology underlying cognitive impairment and CP: neuroplasticity in the shared brain areas, neurotransmitter and other molecular mechanisms. Common mechanisms in CP and depression precipitating cognitive impairment are also discussed. The paper also compares the potential of different antidepressants to improve cognitive functions in depression and CP.

Более половины пациентов с хронической болью (ХБ) предъявляют жалобы на когнитивные нарушения (КН), которые cнижают их трудоспособность и качество жизни. В статье представлен обзор исследований, продемонстрировавших объективные нарушения памяти, внимания, скорости мышления и исполнительной функции при ХБ. Также обсуждаются общие механизмы патогенеза КН и ХБ: нейропластичность в общих зонах головного мозга, нейромедиаторные и другие молекулярные механизмы. Представлен обзор общих патогенетических механизмов депрессии, ХБ и КН. Также приведено сравнение различных антидепрессантов в коррекции КН при депрессии и ХБ.

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