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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Neuromuscular Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Neuromuscular Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Нервно-мышечные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-8721</issn><issn publication-format="electronic">2413-0443</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">310</article-id><article-id pub-id-type="doi">10.17650/2222-8721-2019-9-1-12-23</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURES AND REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИИ И ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Conduction block as an electrophysiological phenomenon: a review of the literature</article-title><trans-title-group xml:lang="ru"><trans-title>Блок проведения возбуждения по периферическому нерву как электрофизиологический феномен: обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3292-2758</contrib-id><name-alternatives><name xml:lang="en"><surname>Nikitin</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Никитин</surname><given-names>С. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>Build. 2, 17 Krzhizhanovskogo St., Moscow 117258</italic></p></bio><bio xml:lang="ru"><p><italic>117258 Москва, ул. Кржижановского, 17/2</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7023-7378</contrib-id><name-alternatives><name xml:lang="en"><surname>Murtazina</surname><given-names>A. F.</given-names></name><name xml:lang="ru"><surname>Муртазина</surname><given-names>А. Ф.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>Build. 2, 17 Krzhizhanovskogo St., Moscow 117258, </italic></p><p><italic>1 Moskvorechye St., Moscow 115522</italic></p></bio><bio xml:lang="ru"><p><bold>Айсылу Фанзировна Муртазина</bold></p><p><italic>117258 Москва, ул. Кржижановского, 17/2, </italic></p><p><italic>115522 Москва, ул. Москворечье, 1</italic></p><p/></bio><email>aysylumurtazina@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6244-0867</contrib-id><name-alternatives><name xml:lang="en"><surname>Druzhinin</surname><given-names>D. S.</given-names></name><name xml:lang="ru"><surname>Дружинин</surname><given-names>Д. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>5 Revolutsionnaya St., Yaroslavl’ 150000</italic></p></bio><bio xml:lang="ru"><p><italic>150000 Ярославль, ул. Революционная, 5</italic></p></bio><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Association of Neuromuscular Disorders Specialists, Medical Center “Practical Neurology”</institution></aff><aff><institution xml:lang="ru">Региональная общественная организация «Общество специалистов по нервно-мышечным болезням», Медицинский центр «Практическая неврология»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Federal State Budgetary Scientific Institution “Research Centre for Medical Genetics”</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Медико-генетический научный центр»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Yaroslavl’ State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-04-24" publication-format="electronic"><day>24</day><month>04</month><year>2019</year></pub-date><volume>9</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>12</fpage><lpage>23</lpage><history><date date-type="received" iso-8601-date="2019-04-24"><day>24</day><month>04</month><year>2019</year></date><date date-type="accepted" iso-8601-date="2019-04-24"><day>24</day><month>04</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Nikitin S.S., Murtazina A.F., Druzhinin D.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Никитин С.С., Муртазина А.Ф., Дружинин Д.С.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Nikitin S.S., Murtazina A.F., Druzhinin D.S.</copyright-holder><copyright-holder xml:lang="ru">Никитин С.С., Муртазина А.Ф., Дружинин Д.С.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://nmb.abvpress.ru/jour/article/view/310">https://nmb.abvpress.ru/jour/article/view/310</self-uri><abstract xml:lang="en"><p>Evaluation and interpretation of electrophysiological phenomena often plays an important role in the diagnosis of neuromuscular diseases. Motor nerve conduction block is a reduction of either amplitude or area of the compound motor action potential elicited by proximal to distal motor nerve stimulation. Today, the value of conduction block in the diagnosis of demyelinating and axonal neuropathies, as well as the diagnostic criteria for these disorders, are still under discussion.</p><p><bold>Objective </bold>of the review of the literature is to highlight the value of conduction block as an electrophysiological phenomenon in the light of clinical manifestations. There is no consensus in the literature which motor response parameters should be used as partial conduction block criteria. The diversity of pathogenic forms in which conduction block can be registered does not allow to consider the phenomenon as a sign of only demyelinating lesions, and the term conduction block should be considered as a pure electrophysiological phenomenon. Different pathophysiological mechanisms of conduction block formation should be studied separately within each nosology. Conduction block detection does not allow to specify a particular diagnosis, however, in conjunction with clinical and anamnestic data, it may be the main argument in the diagnosis of a number of peripheral nerves diseases.</p></abstract><trans-abstract xml:lang="ru"><p>Блок проведения – электрофизиологический феномен снижения амплитуды или площади моторного ответа при стимуляции в проксимальной точке относительно дистального ответа. Сегодня продолжается обсуждение значения блока проведения в диагностике демиелинизирующих и аксональных нейропатий, а также критериев диагностики состояний, при которых регистрируется этот феномен.</p><p><bold>Цель обзора литературы</bold> – осветить тему блока проведения по нерву как электрофизиологического феномена в свете клинических проявлений, для определения его роли в диагностике ряда болезней периферических нервов. В литературе нет единого мнения, какие параметры моторного ответа следует использовать в качестве критериев частичного блока проведения. Разнообразие патогенетических форм, при которых можно обнаружить блок проведения, не позволяет рассматривать этот феномен как признак исключительно демиелинизирующего поражения нервов. Общие и частные патофизиологические механизмы формирования блока проведения при разных нейропатиях необходимо изучать отдельно в рамках каждой нозологической формы. Нозологическая неспецифичность блока приведения не позволяет судить о диагнозе, тем не менее в совокупности с клиническими и анамнестическими данными обнаружение блока приведения может быть основным аргументом в диагностике ряда болезней периферических нервов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>conduction block</kwd><kwd>nerve conduction study</kwd><kwd>temporal dispersion</kwd><kwd>demyelinating neuropathy</kwd><kwd>axonal neuropathy</kwd><kwd>compression neuropathy</kwd><kwd>Guillain–Barre syndrome</kwd><kwd>chronic inflammatory demyelinating polyneuropathy</kwd><kwd>multifocal motor neuropathy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>блок проведения</kwd><kwd>электромиография</kwd><kwd>темпоральная дисперсия</kwd><kwd>демиелинизирующая нейропатия</kwd><kwd>аксональная нейропатия</kwd><kwd>компрессионная нейропатия</kwd><kwd>синдром Гийена–Барре</kwd><kwd>хроническая воспалительная демиелинизирующая полинейропатия</kwd><kwd>мультифокальная моторная нейропатия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Denny-Brown D., Brenner C. 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