Neuromuscular DiseasesNeuromuscular DiseasesНервно-мышечные болезни2222-87212413-0443Publishing House ABV Press3810.17650/2222-8721-2013-0-1-304-312LECTURES AND REVIEWSЛЕКЦИИ И ОБЗОРЫClinical and diagnostic role of autoantibodies to gangliosides of peripheral nerves: literature review and own expirienceКлиническая и диагностическая роль аутоантител к ганглиозидам периферических нервов: обзор литературы и собственные данныеSuponevaN. A.СупоневаН. А.
Russian Federation
nasu2709@mail.ruResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowФГБУ «Научный центр неврологии» РАМН, Москва190520133126341902201519022015Copyright ©; 2013, Suponeva N.A.Copyright ©; 2013, Супонева Н.А.2013Suponeva N.A.Супонева Н.А.https://creativecommons.org/licenses/by/4.0https://nmb.abvpress.ru/jour/article/view/38

The study of anti-glycolipid antibodies has become available to general practice in Russia. Indications for determining antibodies to gangliosidesare Guillain–Barré syndrome, Miller Fisher syndrome, Bickerstaff’s encephalitis, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy. The indication for measuring anti-MAG antibodies is IgM paraprotein-associated polyneuropathy. These immunological tests must be included in diagnostic protocols if the listed dysimmune diseases are suspected.

Исследование антител к гликолипидам периферических нервов стало доступно для широкой практики во многих городах России. Показанием к проведению диагностического теста на определение антиганглиозидных антител является подозрение на синдром Гийена–Барре, синдром Миллера Фишера, энцефалит Бикерстаффа, хроническую воспалительную демиелинизирующую полинейропатию, мультифокальную моторную нейропатию. Показанием к определению анти-MAG-антител служит наличие у больного IgM-парапротеинемической полинейропатии. Зарубежный и отечественный опыт подтверждает необходимость включения этих иммунологических тестов в диагностический протокол исследования больных с подозрением на перечисленные дизиммунные заболевания нервной системы.

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