Neuromuscular DiseasesNeuromuscular DiseasesНервно-мышечные болезни2222-87212413-0443Publishing House ABV Press39410.17650/2222-8721-2020-10-3-10-26LECTURES AND REVIEWSЛЕКЦИИ И ОБЗОРЫCandidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophreniaГены-кандидаты, участвующие в развитии антипсихотик-индуцированной тардивной дискинезии у пациентов с шизофрениейhttps://orcid.org/0000-0001-6836-9590VaimanE. E.ВайманЕ. Э.
Russian Federation

3 Bekhterev St., Saint-Petersburg 192019

192019 Санкт-Петербург, ул. Бехтерева, 3

https://orcid.org/0000-0002-2840-837XShnayderN. A.ШнайдерН. А.
Russian Federation

3 Bekhterev St., Saint-Petersburg 192019

192019 Санкт-Петербург, ул. Бехтерева, 3

https://orcid.org/0000-0001-5618-4206NeznanovN. G.НезнановН. Г.
Russian Federation

3 Bekhterev St., Saint-Petersburg 192019

192019 Санкт-Петербург, ул. Бехтерева, 3

https://orcid.org/0000-0003-1874-9434NasyrovaR. F.НасыроваР. Ф.
Russian Federation

3 Bekhterev St., Saint-Petersburg 192019

Регина Фаритовна Насырова  

192019 Санкт-Петербург, ул. Бехтерева, 3

reginaf@bekhterev.ruNational Medical Research Center of Psychiatry and Neurology named after V.M. Bekhterev, the Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России0612202010310260612202006122020Copyright ©; 2020, Vaiman E.E., Shnayder N.A., Neznanov N.G., Nasyrova R.F.Copyright ©; 2020, Вайман Е.Э., Шнайдер Н.А., Незнанов Н.Г., Насырова Р.Ф.2020Vaiman E.E., Shnayder N.A., Neznanov N.G., Nasyrova R.F.Вайман Е.Э., Шнайдер Н.А., Незнанов Н.Г., Насырова Р.Ф.https://creativecommons.org/licenses/by/4.0https://nmb.abvpress.ru/jour/article/view/394

Introduction. Drug-induced dyskinesia is an iatrogenic undesirable side reaction from the extrapyramidal system that occurs during the administration of drugs, most often antipsychotics in patients with schizophrenia. At the end of the 20 th century, studies were conducted on the search for candidate genes and the carriage of single nucleotide variants of antipsychotics-induced tardive dyskinesia. Purpose of the study – to analyze research results reflecting candidate genes and their single nucleotide variants associated with antipsychotic-induced tardive dyskinesia. Materials and methods. We searched for full-text publications in Russian and English in the eLIBRARY, PubMed, Web of Science, Springer databases using keywords (tardive dyskinesia, drug-induced tardive dyskinesia, antipsychotics, antipsychotics, typical antipsychotics, atypical antipsychotics, genes, polymorphisms) and combined searches for words over the past decade. Results. The lecture discusses candidate genes encoding proteins/enzymes involved in the pharmacodynamics and pharmacokinetics of antipsychotics Conclusion. Timely identification of individual genetic characteristics of the patient can contribute to the development of diagnostic test systems and in the future selection of the safest and most effective antipsychotic therapy.

Введение. Лекарственно-индуцированная дискинезия – ятрогенная нежелательная побочная реакция со стороны экстрапирамидной системы, возникающая на фоне приема лекарственных средств, чаще всего антипсихотиков, у пациентов с шизофренией. В конце XX в. проводились исследования поиска генов-кандидатов и носительства однонуклеотидных вариантов антипсихотик-индуцированной тардивной дискинезии. Цель исследования – проанализировать результаты исследований, описывающих гены-кандидаты и их однонуклеотидные варианты, ассоциированные с антипсихотик-индуцированной тардивной дискинезией. Материалы и методы. Проведен поиск полнотекстовых публикаций на русском и английском языках в базах данных eLIBRARY, PubMed, Web of Science, Springer с использованием ключевых слов (тардивная дискинезия, лекарственно-индуцированная тардивная дискинезия, антипсихотики, нейролептики, типичные антипсихотики, атипичные антипсихотики, гены, полиморфизмы) и комбинированные поиски слов за последнее 10-летие. Результаты. В обзоре рассмотрены гены-кандидаты, кодирующие белки/ферменты, участвующие в фармакодинамике и фармакокинетике антипсихотиков. Заключение. Своевременное выявление генетических особенностей пациента может способствовать разработке диагностических тест-систем и в дальнейшем подбору максимально безопасной и эффективной антипсихотической терапии.

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