Neuromuscular DiseasesNeuromuscular DiseasesНервно-мышечные болезни2222-87212413-0443Publishing House ABV Press39510.17650/2222-8721-2020-10-3-27-34LECTURES AND REVIEWSЛЕКЦИИ И ОБЗОРЫCerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS): literature reviewСиндром мозжечковой атаксии, невропатии и вестибулярной арефлексии (CANVAS): обзор литературыhttps://orcid.org/0000-0003-3179-7668NuzhnyiE. P.НужныйЕ. П.
Russian Federation

80 Volokolamskoe shosse, Moscow 125367

Евгений Петрович Нужный 

125367 Москва, Волоколамское шоссе, 80

enuzhny@mail.ruhttps://orcid.org/0000-0002-2704-6282IllarioshkinS. N.ИллариошкинС. Н.
Russian Federation

80 Volokolamskoe shosse, Moscow 125367

125367 Москва, Волоколамское шоссе, 80

Research Center of NeurologyФГБНУ «Научный центр неврологии»0612202010327340612202006122020Copyright ©; 2020, Nuzhnyi E.P., Illarioshkin S.N.Copyright ©; 2020, Нужный Е.П., Иллариошкин С.Н.2020Nuzhnyi E.P., Illarioshkin S.N.Нужный Е.П., Иллариошкин С.Н.https://creativecommons.org/licenses/by/4.0https://nmb.abvpress.ru/jour/article/view/395

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) is a relatively poorly understood autosomal recessive neurodegenerative disease. The molecular basis of CANVAS was discovered only in 2019 and it is associated with the biallelic pentanucleotide AAGGG expansion carriage in the RFC1 gene. With the advent of genetic diagnostics, the understanding of the phenotypic spectrum and variety of clinical manifestations of this disease has expanded, including a combination of cerebellar ataxia and sensory neuropathy, as well as isolated sensory polyneuropathy/ganglionopathy. This review details current information on the etiology, pathogenesis, clinical presentation and diagnosis of CANVAS in order to increase the awareness of practitioners and early diagnosis of this disease.

Мозжечковая атаксия, невропатия и вестибулярная арефлексия (синдром CANVAS) – относительно малоизученное аутосомнорецессивное нейродегенеративное заболевание, молекулярная основа которого была открыта лишь в 2019 г. и связана с носительством биаллельной пентануклеотидной экспансии AAGGG-повторов в гене RFC1. С появлением возможностей генетической диагностики расширились представления о фенотипическом спектре и разнообразии клинических проявлений данного заболевания, включая сочетание мозжечковой атаксии и сенсорной невропатии, а также изолированной сенсорной полиневропатии/ганглионопатии. В данном обзоре подробно освещены современные сведения об этиологии, патогенезе, клинической картине и диагностике синдрома CANVAS с целью увеличения осведомленности практикующих врачей и своевременной диагностики данного заболевания.

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