Neuromuscular DiseasesNeuromuscular DiseasesНервно-мышечные болезни2222-87212413-0443Publishing House ABV Press7910.17650/2222-8721-2012-0-2-52-58ORIGINAL STUDIESОРИГИНАЛЬНЫЕ СТАТЬИUltrastructural muscle and neuro-muscular junction alterations in polymyositisУльтраструктурные изменения в скелетных мышцах и нервно-мышечных синапсах при полимиозитеBabakovaL. L.БабаковаЛ. Л.
Russian Federation
PozdnyakovO. M.ПоздняковО. М.
Russian Federation
opozdnyakov@rambler.ruThe Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, MoscowФГБУ НИИ общей патологии и патофизиологии РАМН, Москва200420122252582002201520022015Copyright ©; 2012, Babakova L.L., Pozdnyakov O.M.Copyright ©; 2012, Бабакова Л.Л., Поздняков О.М.2012Babakova L.L., Pozdnyakov O.M.Бабакова Л.Л., Поздняков О.М.https://creativecommons.org/licenses/by/4.0https://nmb.abvpress.ru/jour/article/view/79

Ultrastructural analysis of 7 biopsies from m.palmaris longus and m.deltoideus in patients with confirmed polymyositis revealed alterationand degeneration of muscle fibers and anomalies of neuro-muscular junction (NMJ). The NMJ abnormalities and following denervation ofmuscle fibers in polymyositis start with subsynaptic damages. The occurance of regeneration features in muscle fibers at any stage is characteristic for PM.

Ультраструктурное исследование биоптатов длинной ладонной и дельтовидной мышц 7 больных с клиническим диагнозом полимиозита выявило деструктивно-дегенеративные изменения в мышечных волокнах и их синаптическом аппарате. Показано, что нарушение нервно-мышечных контактов и последующая денервация мышечных волокон начинаются с повреждения субсинаптических структур. Наряду с деструктивными выявляются и регенеративные признаки.

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