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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Neuromuscular Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Neuromuscular Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Нервно-мышечные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-8721</issn><issn publication-format="electronic">2413-0443</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">8</article-id><article-id pub-id-type="doi">10.17650/2222-8721-2014-0-1-21-29</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURES AND REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИИ И ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Malignant hyperthermia (icarus syndrome): new view on the old problem</article-title><trans-title-group xml:lang="ru"><trans-title>Злокачественная гипертермия (синдром Икара): новый взгляд на старую проблему</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shnayder</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Шнайдер</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>NASchnaider@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shnayder</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Шнайдер</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Postgraduate Education Institute, Department of Medical Genetics and Clinical Neurophysiology</institution></aff><aff><institution xml:lang="ru">Кафедра медицинской генетики и клинической нейрофизиологии Института последипломного образования ГБОУ ВПО «Красноярский государственный университет им. проф. В.Ф. Войно-Ясенецкого»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Krasnoyarsk Regional Hospital, Division of Anaesthesiology and Rheanimatology</institution></aff><aff><institution xml:lang="ru">отделение анестезиологии и реанимации КГБУЗ «Красноярская краевая клиническая больница»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-04-19" publication-format="electronic"><day>19</day><month>04</month><year>2014</year></pub-date><volume>4</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>21</fpage><lpage>29</lpage><history><date date-type="received" iso-8601-date="2015-02-18"><day>18</day><month>02</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-02-18"><day>18</day><month>02</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Shnayder N.A., Shnayder V.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, Шнайдер Н.А., Шнайдер В.А.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Shnayder N.A., Shnayder V.A.</copyright-holder><copyright-holder xml:lang="ru">Шнайдер Н.А., Шнайдер В.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://nmb.abvpress.ru/jour/article/view/8">https://nmb.abvpress.ru/jour/article/view/8</self-uri><abstract xml:lang="en"><p>In the lecture shot history of research of etiology and pathogenesis of more dramatic complication of general anaesthesia – malignant hyperthermia - are presented. Importance of the interdisciplinary approach to working out of methods of preventive maintenance and treatment of it pharmacogenetics conditions in practice of the anaesthesiologist is underlined.</p></abstract><trans-abstract xml:lang="ru"><p>В лекции освещена краткая история изучения вопросов этиологии и патогенеза одного из наиболее драматических осложнений общей анестезии – злокачественной гипертермии (синдрома Икара). Подчеркнута важность междисциплинарного подхода к разработке методов профилактики и лечения этого фармакогенетического состояния в практике невролога и анестезиолога.</p></trans-abstract><kwd-group xml:lang="en"><kwd>malignant hyperthermia</kwd><kwd>history</kwd><kwd>genetics</kwd><kwd>neuromuscular disorders</kwd><kwd>anaesthesiology.</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>злокачественная гипертермия</kwd><kwd>история</kwd><kwd>генетика</kwd><kwd>нейромышечные болезни</kwd><kwd>анестезиология</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Шнайдер Н.А. Злокачественная гипертермия: генетика, диагностика, профилактика. Острые и неотложные состояния в практике врача 2007;4:32–6.</mixed-citation><mixed-citation xml:lang="ru">Шнайдер Н.А. Злокачественная гипертермия: генетика, диагностика, профилактика. 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