Email this article The diagnosis and pathogenesis of chronic alcoholic myopathy
- Authors: Kazantseva Y.V.1, Zinovyeva O.E.1, Shenkman B.S.2, Shcheglova N.S.1, Lysenko E.A.2
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Affiliations:
- Department of Nervous System Diseases, I.M. Sechenov First Moscow State Medical University
- Institute of Biomedical Problems, Russian Academy of Sciences, Moscow
- Issue: Vol 3, No 2 (2013)
- Pages: 35-38
- Section: ORIGINAL REPORTS
- Published: 20.06.2013
- URL: https://nmb.abvpress.ru/jour/article/view/47
- DOI: https://doi.org/10.17650/2222-8721-2013-0-2-35-38
- ID: 47
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Abstract
Peripheral neuromuscular apparatus lesion is a common complication of chronic alcohol intoxication. Alcohol-induced skeletal muscle disease
is least studied now. A comprehensive clinical, neurophysiological, and morphological examination was made in 42 patients with chronic alcohol
intoxication during this study. All the patients underwent skeletal muscle biopsy followed by muscle fiber morphometry. There was both selective type 2 muscle fiber atrophy and diffuse types 1 and 2 muscle fiber atrophic changes. The clinical manifestations of skeletal muscle disease corresponded to the degree of an atrophic process. There was impairment in the main components of protein synthesis at both intracellular and systemic regulation levels.
About the authors
Yu. V. Kazantseva
Department of Nervous System Diseases, I.M. Sechenov First Moscow State Medical University
Email: fake@neicon.ru
Russian Federation
O. E. Zinovyeva
Department of Nervous System Diseases, I.M. Sechenov First Moscow State Medical University
Author for correspondence.
Email: zinovyevaolga@yandex.ru
Russian Federation
B. S. Shenkman
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
N. S. Shcheglova
Department of Nervous System Diseases, I.M. Sechenov First Moscow State Medical University
Email: fake@neicon.ru
Russian Federation
E. A. Lysenko
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
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