Bruxism: methods of application and results of treatment with botulinum neuroprotein (Relatox)

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Abstract

The article substantiates the need for the use of botulinum therapy in the management of bruxism as a movement disorder. We present the technique of injecting a new Russian botulinum neuroprotein Relatox into the masticatory muscles of patients with bruxism. We have the positive clinical effects of botulinum therapy, a decrease in the level of pain on the visual analogue scale, normalization of muscle activity according to the surface electromyography of masticatory muscles, a decrease in number of nocturnal bruxism according to abrasion on the foil surface on Brux Checker are shown.

About the authors

O. R. Orlova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: ororlova@yandex.ru
ORCID iD: 0000-0003-2225-3642
Build. 2, 8 Trubetskaya St., Moscow 119991, Russia Russian Federation

M. I. Soykher

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-5775-698X
Build. 2, 8 Trubetskaya St., Moscow 119991, Russia Russian Federation

M. G. Soykher

Kazan State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-1811-3786
49 Butlerova Street, Kazan 420012, Russia Russian Federation

L. R. Mingazova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-6164-9810
Build. 2, 8 Trubetskaya St., Moscow 119991, Russia Russian Federation

D. V. Medovnikova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0001-5032-2460
Build. 2, 8 Trubetskaya St., Moscow 119991, Russia Russian Federation

E. M. Soykher

Center of Interdisciplinary Dentistry and Neurology

Email: fake@neicon.ru
ORCID iD: 0000-0003-2057-4485
Build. 2, 32 Komsomol’skiy Prospekt, Moscow 119146, Russia Russian Federation

Z. N. Konovalova

Central Institute of Botulinotherapy and Actual Neurology

Email: fake@neicon.ru
ORCID iD: 0000-0003-1906-8323
Build. 1B, 6 Marshala Rokossovskogo Bul’var, Moscow 107370, Russia Russian Federation

A. Yu. Alekseeva

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-3361-9155
Build. 2, 8 Trubetskaya St., Moscow 119991, Russia Russian Federation

References

  1. Orlova O.R., Alekseeva A.Yu., Mingazova L.R., Konovalova Z.N. Bruxism as a neurological problem (literature review). Nervno-myshechnye bolezni = Neuromuscular Diseases 2018;8(1):20–7. (In Russ.)]. doi: 10.17650/2222-8721-2018-8-1-20-27.
  2. Castrillon E.E., Ou K.L., Wang K. et al. Sleep bruxism: an updated review of an old problem. Acta Odontol Scand 2016;74(5):328–34. doi: 10.3109/00016357.2015.1125943. PMID: 26758348.
  3. Ella B., Ghorayeb I., Burbaud P. et al. Bruxism in movement disorders: a comprehensive review. J Prosthodont 2017;26(7):599–605. doi: 10.1111/jopr.12479. PMID: 27077925.
  4. Zucconi M., Ferri R. Assessment of sleep disorders and diagnostic procedures. Sleep medicine textbook chapter B1. Milan: European Sleep Research Society, 2014. Pp. 95–109.
  5. Orlova O.R., Alekseeva A.Yu., Konovalova Z.N. Botulinum therapy in the treatment of bruxism. Metamorfozy = Metamorphosis 2018;22:92–4. (In Russ.).
  6. Certificate of state registration of computer program №2017619272 “BruxDiagnostic”. Copyright holders Shershneva D.V. (Medovnikova D.V.), Soykher M.G. (In Russ.).
  7. Soykher M.G., Soykher M.I., Shershneva D.V. (Medovnikova D.V.) et al. Total bioelectric activity of the masticatory muscles in healthy patients and patients with bruxism. Stomatologiya detskogo vozrasta i profilaktika = Pediatric dentistry and prevention 2017;16;3(62):54–7. (In Russ.).
  8. Orlova, O.R., Konovalova, Z.N., Mingazova, L.R. et al. Experience of using new botulinum toxin type A Relatoks® in clinical practice. Metamorfozy = Metamorphosis 2014;11;2–4. (In Russ.).
  9. Lee H.J., Kang I.W., Seo K.K. et al. The anatomical basis of paradoxical masseteric bulging after botulinum neurotoxin type a injection. Toxins 2017;9:14. doi: 10.3390/toxins9010014. PMID: 28042813.
  10. Aoki K.R. Review of a proposed mechanism for the antinociceptive action of botulinumtoxin type A. Neuro Toxicology 2005;26:785–93. doi: 10.1016/j.neuro.2005.01.017. PMID: 16002144.
  11. Orlova O.R., Konovalova Z.N., Alekseeva A.Yu. et al. The relationship of bruxism and pain dysfunction of the temporomandibular joint. Russkiy medicinskiy zhurnal. Bolevoy syndrom = Russian medical journal. Pain syndrome 2017;24:1760–3. (In Russ.).
  12. Orlova O.R., Alekseeva A.Yu., Konovalova Z.N. et al. Possibilities of the analgesic action of botulinum therapy in clinical practice. Terapiya = Therapy 2018;7(25):52–6. (In Russ.).
  13. McCoy G. Dental compression syndrome: a new look at an old disease. J Oral Implantol 1999;25(1):35–49. doi: 10.1563/1548-1336(1999)025<0035: DCSANL>2.3.CO;2. PMID: 10483426.

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Copyright (c) 2019 Orlova O.R., Soykher M.I., Soykher M.G., Mingazova L.R., Medovnikova D.V., Soykher E.M., Konovalova Z.N., Alekseeva A.Y.

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