Ацетил-L-карнитин при дистимических расстройствах в пожилом возрасте: двойное слепое, мультицентровое, контролируемое рандомизированное исследование в сравнении с флуоксетином

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Giuseppe Bersania

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy

Автор, ответственный за переписку.
Email: giuseppe.bersani@uniroma1.it
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Giuseppe Meco

Department of Neurology and Psychiatry, Sapienza University of Rome, Italy

Email: fake@neicon.ru
Россия

Alessandro Denaro

Department of Neuromotor Rehabilitation, Istituto Chirurgico Ortopedico Traumatologico (ICOT), Latina, Italy

Email: fake@neicon.ru
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Damien Liberati

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy

Email: fake@neicon.ru
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Chiara Colletti

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy

Email: fake@neicon.ru
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Raffaella Nicolai

Corporate R&D Sigma-Tau S.p.A., Pomezia, Italy

Email: fake@neicon.ru
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Francesco Saverio Bersania

Department of Neurology and Psychiatry, Sapienza University of Rome, Italy

Email: fake@neicon.ru
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Aleardo Koverech

Carnitine Development Dept., Sigma-Tau S.p.A., Pomezia, Italy

Email: fake@neicon.ru
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Список литературы

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  2. Bahring R., Standhardt H., Arrigoni Martelli E., Grantyn R. GABAactivated chloride currents of Postnatal mouse retinal ganglion cells are blocked by Acetylcholine and Acetylcarnitine: how specific are ion channel in immature neurons. Eur J Neurosci 1994;6,1089–9 9.
  3. Bella R., Biondi R., Raffaele R., Pennisi G. Effect of acetyl-L-carnitine on geriatric patients suffering from dysthymic disorders. Int J Clin Pharmacol Res 1990;10(6):355–60.
  4. Chiechio S., Copani A., DePetris L. et al. Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NFkappa B pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine. Mol Pain 2006;2:20–8.
  5. Chiechio S., Copani A., Zammataro M. et al. Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain. Trends Pharmacol Sci 2010;31(4):153–60.
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  11. Madiraju P., Pande S.V., Prentki M., Madiraju S.R. Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation. Epigenetics 2009;4: 399–403.
  12. Masi F., Leggio B., Nanni G. et al. Effects of long-term acetyl-L-carnitine administration in Rats-II: Protection against the disrupting effect of stress on the acquisition of appetitive behavior. Neuropsychopharmacology 2003;28(4):683–93.
  13. Pettegrew J.W., Levine J., McClure R.J. Acetyl-L-carnitine physical–chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer’s disease and geriatric depression.Mol Psychiatry 2000;5(6):616–32.
  14. Pettegrew J.W., Levine J., Gershon S. et al. 31P-MRS study of acetyl-L-carnitine treatment in geriatric depression: preliminary results. Bipolar Disord 2002;4(1):61–6.
  15. Pisano C., Pratesi G., Laccabue D. et al. Paclitaxel and cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. Clin Cancer Res 2003;9(15):5756–67.
  16. Pulvirenti G., Valerio C.,Spadaio F. et al. Acetylcarnitine reduces the immobility of rats in a despair test. Behav Neural Biol 1990;54(2):110–4.
  17. Ricciolini R., Scalibastri M., Kelleher J.K. Role of acetyl-L-carnitine in rat brain lipogenesis: implications for polyunsaturated fatty acid biosynthesis. J Neurochem 1998;71(6):2510–17.
  18. Rosca M.G., Lemieux H., Hoppel C.L. Mitochondria in the elderly: is acetylcarnitine a rejuvenator? Adv Drug Deliver Rev 2009;61(14);1332–42.
  19. Taglialatela G., Navarra D., Cruciani R. et al. Acetyl-L-carnitine treatment increase nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp Gerontol1994;29(1);55–66.
  20. Tempesta E., Janiri L., Pirrongelli C. Stereospec ificeffects of acetylcarnitine on the spontaneous activity of brainstem neurones and their responses to acetylcholine andserotonin. Neuropharmacology 1985;24(1):43–50.
  21. Tempesta E., Casella L., Pirrongelli C. et al. L-acetylcarnitine in depressed elderly subjects. Across-over study vs placebo. Drugs Exp Clin Res 1987;13(7):417–23.
  22. Tolu P., Masi F., Leggio B. et al. Effects of long-term acetyl-L-carnitine administration in rats. Increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure. Neuropsychopharmacology 2002;27(3):410–20.
  23. Valente M., Koverech A., Canonico P., Grilli M.G. Acetyl-L-carnitine, a new pharmacological modulator of adult hippocampal neurogenesis. Program no. 907.22PosterMM29. 2011 Neuroscience Meeting Planner. Washington, DC, Society for Neuroscience, 2011(online).
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© Bersania G., Meco G., Denaro A., Liberati D., Colletti C., Nicolai R., Bersania F., Koverech A., 2014

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