Email this article Dynamics of electrophysiological parameters of distal symmetric polyneuropathy in the course of pregnancy of women with type 1 diabetes mellitus
- Authors: Poroshnichenko A.I.1,2, Burshinov A.O.3,4
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Affiliations:
- Ryazan Department of State Budgetary Institution «Regional Clinical Perinatal Center»
- 1i Internatsionalnaya St., Ryazan, 390039, Russia
- State Budgetary Educational Institution of Higher Vocational Education «I. P. Pavlov Ryazan State Medical University» with Ministry of Health of Russia
- 9 Vysokovoltnaya St., Ryazan, 390026, Russia
- Issue: Vol 5, No 3 (2015)
- Pages: 37-41
- Section: ORIGINAL REPORTS
- Published: 21.09.2015
- URL: https://nmb.abvpress.ru/jour/article/view/122
- DOI: https://doi.org/10.17650/2222-8721-2015-5-3-37-41
- ID: 122
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Abstract
Objective of the study: assessment of clinical and electroneuromyographic (ENMG) parameters of distal symmetric polyneuropathy during pregnancy.
Materials and methods. 32 pregnant women with type I diabetes mellitus were examined. Signs of diabetic polyneuropathy (DPNP) were revealed in 87.5 percent (n = 28) of patients. Duration of diabetes in patients with DPNP varied from 1 to 30 years (in average, 11.0 ± 6.4 years). Subjective (NSS scale) and objective assessment (NDS scale) of neuropathy symptoms, as well as the nerve conduction studies of the peroneal, tibial, and sural nerves were performed twice, on the 15–16 and 32–33 weeks of pregnancy.
Results. Increase in subjective and objective symptoms of polyneuropathy along the pregnancy according to NSS and NDS scales (р < 0.05), as well as significant decrease of CMAP and SNAP amplitudes (р < 0.05) in the second half of pregnancy, indicating the progression of the DPNP. The most frequent pathological changes were observed in the peroneal and sural nerves.
Conclusions. Pregnancy has an adverse effect on the course of the DPNP contributing to the axonal damage of peripheral nerves, progression of neurological impairment and aggravation of subjective neuropathic symptoms.
About the authors
A. I. Poroshnichenko
Ryazan Department of State Budgetary Institution «Regional Clinical Perinatal Center»;1i Internatsionalnaya St., Ryazan, 390039, Russia
Author for correspondence.
Email: neyrogin@gmail.com
Russian Federation
A. O. Burshinov
State Budgetary Educational Institution of Higher Vocational Education «I. P. Pavlov Ryazan State Medical University» with Ministry of Health of Russia; 9 Vysokovoltnaya St., Ryazan, 390026, Russia
Email: fake@neicon.ru
Russian Federation
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