Epidemiologic studies of myasthenia gravis: literature review

Cover Page

Cite item

Full Text

Abstract

The review of domestic and foreign literature devoted to epidemiological studies of myasthenia gravis has been reviewed. The article presents data on the prevalence and incidence of myasthenia gravis in several regions of Russia and abroad. The prevalence of myasthenia gravis in the world varies, according to different authors, in a very wide range – from 2.17 to 32.0 per 100 thousand people. There are few epidemiological studies of myasthenia gravis in large cities and regions of Russia. Meanwhile, studies of the prevalence and incidence of myasthenia gravis are a necessary stage in the work to increase the effectiveness of diagnosis and treatment of this pathology, to determine the need for specialized types of medical care. The results of these studies can be used to optimize the management of myasthenia gravis patients.

About the authors

T. M. Alekseeva

V.A. Almazov National Medical Research Center, Ministry of Health of Russia.

Author for correspondence.
Email: fake@neicon.ru
ORCID iD: 0000-0002-4441-1165
2 Akkuratova St., Saint Petersburg 197341. Russian Federation

V. V. Kryuchkova

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia.

Email: valentina2107@yahoo.com
ORCID iD: 0000-0002-9642-0899
41 Kirochnaya St., Saint Petersburg 191015. Russian Federation

T. R. Stuchevskaya

City Multi-Specialty Hospital No. 2.

Email: fake@neicon.ru
Uchebnyy Pereulok, Saint Petersburg 194354. Russian Federation

A. N. Khalmurzina

V.A. Almazov National Medical Research Center, Ministry of Health of Russia.

Email: fake@neicon.ru
ORCID iD: 0000-0003-3831-5238
2 Akkuratova St., Saint Petersburg 197341. Russian Federation

References

  1. Gekht B. M. Treatment of myasthenia gravis. Nevrologicheskiy zhurnal = Neurological Journal 2000;1:4–9. (In Russ.).
  2. Guptill J. T., Marano A., Krueger A., Sanders D. B. Cost analysis of myasthenia gravis from a large U. S. insurance database. Muscle Nerve 2011;44(6): 907–11. doi: 10.1002/mus.22212. PMID: 22102461.
  3. Poulas K., Tsibri E., Kokla A. et al. Epidemiology of seropositive myasthenia gravis in Greece. J Neurol Neurosurg Psychiatry 2001;71(3):352–6. doi: 10.1136/jnnp.71.3.352. PMID: 11511710
  4. Romanova T. V. Samara epidemiological research of myasthenia gravis. Saratovskiy nauchno-meditsinskiy zhurnal = Saratov Journal of Medical Scientific Research 2012;8(1):91–5. (In Russ.).
  5. Zaslavskiy L. G., Hurshilov A. B. Main clinic and epidemiological factors of myasthenia gravis in the Leningrad Region. Uchenie zapiski SPbGMU im. akad. I. P. Pavlova = Record of the I. P. Pavlov Saint-Petersburg State Medical University 2015;22(4):40–3. (In Russ.).
  6. Gasymly E. D., Isaeva N. V., Prokopenko S. V., Andon Yu. N. Epidemiological and clinical characteristics of myasthenia in the Krasnoyarsk region. Nervno-myshechnye bolezni = Neuromuscular Diseases 2017;7(4):33–8. (In Russ.). doi: 10.17650/2222-8721-2017-7-4-33-38.
  7. Sidorova O. P., Neretin V. Ya., Agafonov B. V., Andreeva I. L. Clinical and populational analysis of myasthenia gravis in adults of the Moscow Region. Almanakh klinicheskoy meditsiny = Almanac of Clinical Medicine 2006. P. 109–113. (In Russ.).
  8. Khatkhe Yu. A., Zabolotskikh N. V., Terpelets S. A. Epidemiologic and populational aspects of myasthenia gravis in the Krasnodar Region. Nervno-myshechnye bolezni = Neuromuscular Diseases 2018;8(1):28– 33. (In Russ.). DOI:10.17650/ 2222-8721-2018-8-1-28-33.
  9. Likhachev S. A., Kulikova S. L., Astapenko A. V. Epidemiology of myasthenia gravis in the Republic of Belarus. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova = S. S. Korsakov Journal of Neurology and Psychiatry 2014;114(1):54–7. (In Russ.).
  10. Hokkanen E. Epidemiology of myasthenia gravis in Finland. J Neurol Sci 1969;9(3):463–78. doi: 10.1016/0022-510X(69)90090–2. PMID: 5367040.
  11. Storm-Mathisen A. Epidemiology of myasthenia gravis in Norway. Acta Neurol Scand 1984;70(4):274–84. doi: 10.1111/j.1600-0404.1984.tb00825.x. PMID: 6507037.
  12. Oopik M., Kaasik A., Jakobsen J. A population based epidemiological study on myasthenia gravis in Estonia. J Neurol Neurosurg Psychiatry 2003;74(12):1638–43. doi: 10.1136/jnnp.74.12.1638. PMID: 14638881.
  13. Santos E., Coutinho E., Moreira I. et al. Epidemiology of myasthenia gravis in Northern Portugal: frequency estimates and clinical epidemiological distribution of cases. Muscle Nerve 2016;54(3):413–21. doi: 10.1002/mus.25068. PMID: 26851892. 1
  14. Pedersen E. G., Hallas J., Hansen K. et al. Late-onset myasthenia not on the increase: a nationwide register study in Denmark, 1996–2009. Eur J Neurol 2013;20(2):309–14. doi: 10.1111/j.1468-1331.2012.03850.x. PMID: 22882327.
  15. Gattellari M., Goumas C., Worthington J. M. A national epidemiological study of Myasthenia Gravis in Australia. Eur J Neurol 2012;19(11):1413–20. DOI: 10.1111/j. 1468-1331.2012.03698.x. PMID: 22469211.
  16. Park S. Y., Lee J. Y., Lim N. G., Hong Y. H. Incidence and prevalence of myasthenia gravis in Korea: a population-based study using the national health insurance claims database. J Clin Neurol (Korea) 2016;12(3):340–4. doi: 10.3988/jcn.2016.12.3.340. PMID: 27165426.
  17. Tiamkao S., Pranboon S., Thepsuthammarat K., Sawanyawisuth K. Prevalence of factors associated with poor outcomes of hospitalized myasthenia gravis patients in Thailand. Neurosciences (Riyadh) 2014;19(4):286–90. PMID: 25274587.
  18. Lai C. H., Tseng H. F. Nationwide population-based epidemiological study of myasthenia gravis in Taiwan. Neuroepidemiology 2010;35(1):66–71. doi: 10.1159/000311012. PMID: 20523074.
  19. Breiner A., Widdifield J., Katzberg H. D. et al. Epidemiology of myasthenia gravis in Ontario, Canada. Neuromuscul Disord 2016;26(1):41–6. doi: 10.1016/j.nmd.2015.10.009. PMID: 26573434.
  20. Martinka I., Fulova M., Spalekova M., Spalek P. Epidemiology of myasthenia gravis in Slovakia in the years 1977–2015. Neuroepidemiology 2018;50(3–4):153–9. doi: 10.1159/000487886.PMID: 29558746.
  21. Zieda A., Ravina K., Glazere I. et al. A nationwide epidemiological study of myasthenia gravis in Latvia. Eur J Neurol 2018;25(3):519–26. doi: 10.1111/ene.13535. PMID: 29194859.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Alekseeva T.M., Kryuchkova V.V., Stuchevskaya T.R., Khalmurzina A.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 85909 от  25.08.2023.