Хроническая боль, депрессия и когнитивные нарушения: тесные взаимосвязи
Аннотация
Более половины пациентов с хронической болью (ХБ) предъявляют жалобы на когнитивные нарушения (КН), которые cнижают их трудоспособность и качество жизни. В статье представлен обзор исследований, продемонстрировавших объективные нарушения памяти, внимания, скорости мышления и исполнительной функции при ХБ. Также обсуждаются общие механизмы патогенеза КН и ХБ: нейропластичность в общих зонах головного мозга, нейромедиаторные и другие молекулярные механизмы. Представлен обзор общих патогенетических механизмов депрессии, ХБ и КН. Также приведено сравнение различных антидепрессантов в коррекции КН при депрессии и ХБ.
Об авторах
Н. В. Латышева
ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России; Клиника головной боли и вегетативных расстройств им. акад. Александра Вейна.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
125130 Москва, Старопетровский проезд, 10б.
Е. Г. Филатова
ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России; Клиника головной боли и вегетативных расстройств им. акад. Александра Вейна.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
125130 Москва, Старопетровский проезд, 10б.
Д. В. Осипова
ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2.
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Рецензия
Для цитирования:
Латышева Н.В., Филатова Е.Г., Осипова Д.В. Хроническая боль, депрессия и когнитивные нарушения: тесные взаимосвязи. Нервно-мышечные болезни. 2018;8(3):34-42. https://doi.org/10.17650/2222-8721-2018-8-3-34-42
For citation:
Latysheva N.V., Filatova E.G., Osipova D.V. Chronic pain, depression and cognitive impairment: a close relationship. Neuromuscular Diseases. 2018;8(3):34-42. (In Russ.) https://doi.org/10.17650/2222-8721-2018-8-3-34-42
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