Хроническая боль, депрессия и когнитивные нарушения: тесные взаимосвязи
Аннотация
Более половины пациентов с хронической болью (ХБ) предъявляют жалобы на когнитивные нарушения (КН), которые cнижают их трудоспособность и качество жизни. В статье представлен обзор исследований, продемонстрировавших объективные нарушения памяти, внимания, скорости мышления и исполнительной функции при ХБ. Также обсуждаются общие механизмы патогенеза КН и ХБ: нейропластичность в общих зонах головного мозга, нейромедиаторные и другие молекулярные механизмы. Представлен обзор общих патогенетических механизмов депрессии, ХБ и КН. Также приведено сравнение различных антидепрессантов в коррекции КН при депрессии и ХБ.
Об авторах
Н. В. ЛатышеваРоссия
119991 Москва, ул. Трубецкая, 8, стр. 2;
125130 Москва, Старопетровский проезд, 10б.
Е. Г. Филатова
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
125130 Москва, Старопетровский проезд, 10б.
Д. В. Осипова
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2.
Список литературы
1. Prefontaine K., Rochette A. A literature review on chronic pain: the daily overcoming of a complex problem. Br J Occupat Ther 2013;76(6):280–6. DOI: 10.4276/030802213x13706169932905.
2. Breivik H., Collett B., Ventafridda V. et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 2006;10(4):287–333. DOI: 10.1016/j.ejpain.2005.06.009. PMID: 16095934.
3. Landrø N., Fors E., Våpenstad L. et al. The extent of neurocognitive dysfunction in a multidisciplinary pain centre population. Is there a relation between reported and tested neuropsychological functioning? Pain 2013;154(7):972–7. DOI: 10.1016/j.pain.2013.01.013. PMID: 23473784.
4. Mazza S., Frot M., Rey A. A comprehensive literature review of chronic pain and memory. Prog Neuropsychophar macol Biol Psychiatry 2017;87(Pt B): 183–92. DOI: 10.1016/j.pnpbp.2017.08.006. PMID: 28797640.
5. Morone N., Abebe K., Morrow L. et al. Pain and decreased cognitive function negatively impact physical functioning in older adults with knee osteoarthritis. Pain Med 2014;15(9):1481–7. DOI: 10.1111/pme.12483. PMID: 25040845.
6. Bell T., Trost Z., Buelow M. et al. Meta-analysis of cognitive performance in fibromyalgia. J Clin Exp Neuropsychol 2018;40(7):698–714. DOI: 10.1080/13803395.2017.1422699. PMID: 29388512.
7. Bertolucci P., de Oliveira F. Cognitive impairment in fibromyalgia. Curr Pain Headache Rep 2013;17(7):344. DOI: 10.1007/s11916-013-0344-9. PMID: 23709236.
8. Tesio V., Torta D., Colonna F. et al. Are fibromyalgia patients cognitively impaired? Objective and subjective neuropsychological evidence. Arthritis Care Res (Hoboken) 2015;67(1):143–50. DOI: 10.1002/acr.22403. PMID: 25047247.
9. Berryman C., Stanton T. R., Bowering J. et al. Evidence for working memory deficits in chronic pain: a systematic review and meta-analysis. Pain 2013;154(8):1181–96. DOI: 10.1016/j.pain.2013.03.002. PMID: 23707355.
10. Moriarty O., Ruane N., O’Gorman D. et al. Cognitive impairment in patients with chronic neuropathic or radicular pain: an interaction of pain and age. Front Behav Neurosci 2017;11:100. DOI: 10.3389/fnbeh.2017.00100. PMID: 28659771.
11. Apkarian A., Sosa Y., Krauss B. et al. Chronic pain patients are impaired on an emotional decision-making task. Pain 2004;108(1–2):129–36. DOI: 10.1016/j.pain.2003.12.015. PMID: 15109516.
12. Baker K., Gibson S., GeorgiouKaristianis N. et al. Everyday executive functioning in chronic pain: specific deficits in working memory and emotion control, predicted by mood, medications, and pain interference. Clin J Pain 2016;32(8):673–80. DOI: 10.1097/AJP. 0000000000000313. PMID: 26626294.
13. Ferreira K., Oliver G., Thomaz D. et al. Cognitive deficits in chronic pain patients, in a brief screening test, are independent of comorbidities and medication use. Arq Neuropsiquiatr 2016;74(5):361–6. DOI: 10.1590/0004-282X20160071. PMID: 27191230
14. Латышева Н. В., Филатова Е. Г., Осипова Д. В. Нарушения памяти и внимания у пациентов с хронической мигренью. Нервно-мышечные болезни 2018;8(2):10–6.
15. Leavitt F., Katz R. Speed of mental operations in fibromyalgia: a selective naming speed deficit. J Clin Rheumatol 2008;14(4):214–8. DOI: 0.1097/rhu. 0b013e31817a2472. PMID: 18636019.
16. Veldhuijzen D., van Wijck A., Wille F. et al. Effect of chronic nonmalignant pain on highway driving performance. Pain 2006;122(1–2):28–35. DOI: 10.1016/j.pain.2005.12.019. PMID: 16495013.
17. Eccleston C. Chronic pain and attention: a cognitive approach. Br J Clin Psychol 1994;33(Pt 4):535–47. DOI: 10.1111/j.2044-8260.1994.tb01150.x. PMID: 7874045.
18. Baliki M., Schnitzer T., Bauer W., Apkarian A. V. Brain morphological signatures for chronic pain. PLoS One 2011;6(10):e26010. DOI: 10.1371/ journal.pone.0026010. PMID: 22022493
19. Apkarian A., Sosa Y., Sonty S. et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 2004;24(46); 10410–5. DOI: 10.1523/JNEUROSCI. 2541–04.2004. PMID: 15548656.
20. Moriarty O., McGuire B., Finn D. The effect of pain on cognitive function: a review of clinical and preclinical research. Prog Neurobiol 2011;93(3):385–404. DOI: 10.1016/j.pneurobio.2011.01.002. PMID: 21216272.
21. Luerding R., Weigand T., Bogdahn U. et al. Working memory performance is correlated with local brain morphology in the medial frontal and anterior cingulate cortex in fibromyalgia patients: structural correlates of pain-cognition interaction. Brain 2008;131(Pt 12):3222–31. DOI: 10.1093/brain/awn229. PMID: 18819988.
22. Foti M., Lo Buono V., Corallo F. et al. Neuropsychological assessment in migraine patients: a descriptive review on cognitive implications. Neurol Sci 2017;38(4):553–62. DOI: 10.1007/s10072-017-2814-z. PMID: 28101762.
23. Baliki M., Petre B., Torbey S. et al. Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci 2012;15(8):1117–9. DOI: 10.1038/nn.3153. PMID: 22751038.
24. Fallon N., Chiu Y., Nurmikko T., Stancak A. Functional connectivity with the default mode network is altered in fibromyalgia patients. PLoS One 2016;11(7):e0159198. DOI: 10.1371/ journal.pone.0159198. PMID: 27442504.
25. Grilli M. Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies. J Pain Res 2017;10:2281–6. DOI: 10.2147/JPR.S146399. PMID: 29033604.
26. Vachon-Presseau E., Tétreault P., Petre B. et al. Corticolimbic anatomical characteristics predetermine risk for chronic pain. Brain 2016;139(Pt 7):1958–70. DOI: 10.1093/brain/aww100. PMID: 27190016.
27. Barthas F., Sellmeijer J., Hugel S. et al. The anterior cingulate cortex is a critical hub for pain-induced depression. Biol Psychiatry 2015;77(3):236–45. DOI: 10.1016/j.biopsych.2014.08.004. PMID: 25433903.
28. Ebert D., Ebmeier K. The role of the cingulate gyrus in depression: from functional anatomy to neurochemistry. Biol Psychiatry 1996;39(12):1044–50. DOI: 10.1016/0006-3223(95)00320-7. PMID: 8780840.
29. Salzman C., Fusi S. Emotion, cognition, and mental state representation in amygdala and prefrontal cortex. Annu Rev Neurosci 2010;33:173–202. DOI: 10.1146/annurev.neuro. 051508.135256. PMID: 20331363.
30. Nekovarova T., Yamamotova A., Vales K. et al. Common mechanisms of pain and depression: are antidepressants also analgesics? Frontiers in Behavioral Neurosci 2014;8:99. DOI: 10.3389/fnbeh.2014.00099. PMID: 24723864.
31. Bai Y., Chiou W., Su T. et al. Proinflammatory cytokine associated with somatic and pain symptoms in depression. J Affect Disord 2014;155:28–34. DOI: 10.1016/j.jad.2013.10.019. PMID: 24176538.
32. Uçeyler N., Valenza R., Stock M. et al. Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. Arthritis Rheum 2006;54(8):2656–64. DOI: 10.1002/art.22026. PMID: 16871547.
33. Cowen P., Sherwood A. The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. J Psychopharmacol 2013;27(7):575–83. DOI: 10.1177/0269881113482531. PMID: 23535352.
34. Baune B., Brignone M., Larsen K. A network meta-analysis comparing effects of various antidepressant classes on the digit symbol substitution test(DSST) as a measure of cognitive dysfunction in patients with major depressive disorder. Int J Neuropsychopharmacol 2018;21(2): 97–107. DOI: 10.1093/ijnp/pyx070. PMID: 29053849.
35. Naser P., Kuner R. Molecular, cellular and circuit basis of cholinergic modulation of pain. Neurosci 2018;387:135–48. DOI: 10.1016/j.neuroscience. 2017.08.049. PMID: 28890048.
36. Aurora S., Brin M. F. Chronic migraine: an update on physiology, imaging, and the mechanism of action of two available pharmacologic therapies. Headache 2017;57(1):109–25. DOI: 10.1111/head.12999. PMID: 27910097.
37. Mainero C., Boshyan J., Hadjikhani N. Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine. Ann Neurol 2011;70(5):838–45. DOI: 10.1002/ana.22537. PMID: 22162064.
38. Kim J., Suh S., Seol H. et al. Regional grey matter changes in patients with migraine: a voxel-based morphometry study. Cephalalgia 2008;28(6):598–604. DOI: 10.1111/j.1468-2982.2008.01550.x. PMID: 18422725.
39. Riederer F., Marti M., Luechinger R. et al. Grey matter changes associated with medication-overuse headache: correlations with disease related disability and anxiety. World J Biol Psychiatry 2012:13(7):517–25. DOI: 10.3109/15622975.2012.665175. PMID: 22746999.
40. Lai T., Wang S. Neuroimaging findings in patients with medication overuse headache. Curr Pain Headache Rep 2018;22(1):1. DOI: 10.1007/ s11916-018-0661-0. PMID: 29340793.
41. Biagianti B., Grazzi L., Gambini O. et al. Decision-making deficit in chronic migraine patients with medication overuse. Neurol Sci 2012;33 Suppl 1: S151–5. DOI: 10.1007/s10072-012-1071-4. PMID: 22644192.
42. Gwilym S., Filippini N., Douaud G. et al. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum. 2010;62(10):2930–40. DOI: 10.1002/ art.27585. PMID: 20518076.
43. Головачева В. А., Парфенов В. А., Головачева А. А. Когнитивные жалобы и нарушения у пациентов с хронической ежедневной головной болью. Неврология, нейропсихиатрия, психосоматика 2017;9(4):55–9.
44. Costa A., Sansalone A., Squillace A. et al. Self-referred cognitive impairment in migraine patients. J Headache Pain 2015;16:A149. DOI: 10.1186/1129-2377-16-S1-A149. PMID: 28132239.
45. Lai T., Protsenko E., Cheng Y. et al. Neural plasticity in common forms of chronic headaches. Neural Plast 2015;2015:205985. DOI: 10.1155/2015/ 205985. PMID: 26366304.
46. Fumal A., Laureys S., Di Clemente L. et al. Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain 2006:129(2);543–50. DOI: 10.1093/brain/ awh691. PMID: 16330505.
47. Lam R., Kennedy S., Mclntyre R. et al. Cognitive dysfunction in major depressive disorder: effects on psychosocial functioning and implications for treatment. Can J Psychiatry 2014;59(12):649–54. DOI: 10.1177/070674371405901206. PMID: 25702365.
48. McIntyre R., Soczynska J., Woldeyohannes H. et al. The impact of cognitive impairment on perceived workforce performance: results from the International Mood Disorders Collaborative Project. Compr Psychiatry 2015;56:279–82. DOI: 10.1016/j.comppsych.2014.08.051. PMID: 25439523.
49. Carvalho A., Miskowiak K., Hyphantis T. et al. Cognitive dysfunction in depression – pathophysiology and novel targets. CNS Neurol Disord Drug Targets 2014;13(10):1819–35. DOI: 10.2174/1871527313666141130203627. PMID: 25470397.
50. Yamamoto T., Shimada H. Cognitive dysfunctions after recovery from major depressive episodes. Appl Neuropsychol Adult 2012;19(3):183–91. DOI: 10.1080/09084282.2011.643959. PMID: 23373604.
51. McKinnon M., Yucel K., Nazarov A. et al. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 2009;34(1):41–54. PMID: 19125212.
52. Videbech P., Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004;161(11):1957–66. DOI: 10.1176/ appi.ajp.161.11.1957. PMID: 15514393.
53. Arnone D., McIntosh A., Ebmeier K. et al. Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses. Eur Neuropsychopharmacol 2012;22(1):1–16. DOI: 10.1016/j.euroneuro.2011.05.003. PMID: 21723712.
54. Gao Y., Huang C., Zhao K. et al. Depression as a risk factor for dementia and mild cognitive impairment: a metaanalysis of longitudinal studies. Int J Geriatr Psychiatry 2013;28(5):441–9. DOI: 10.1002/gps.3845. PMID: 22815126.
55. Gould E., McEwen B., Tanapat P. et al. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997;17(7):2492–8. DOI: 10.1523/jneurosci.17-07- 02492.1997. PMID: 9065509.
56. Dias-Ferreira E., Sousa J., Melo I. et al. Chronic stress causes frontostriatal reorganization and affects decisionmaking. Science 2009;325(5940):621–5. DOI: 10.1126/science.1171203. PMID: 19644122.
57. Heiser P, Lanquillon S, Krieg J. Differential modulation of cytokine production in major depressive disorder by cortisol and dexamethasone. Eur Neuropsychopharmacol 2008;18(12):860–70. DOI: 10.1016/j.euroneuro.2008.07.003. PMID: 18775652.
58. Young A. H. The effects of HPA axis function on cognition and its implications for the pathophysiology of bipolar disorder. Harv Rev Psychiatry 2014; 22(6):331–3. DOI: 10.1097/HRP. 0000000000000020. PMID: 25377604.
59. Dick B., Eccleston C., Crombez G. Attentional functioning in fibromyalgia, rheumatoid arthritis, and musculoskeletal pain patients. Arthritis Rheum 2002;47(6):639–44. DOI: 10.1002/art. 10800. PMID: 12522838
60. Мелкумова К. А., Подчуфарова Е. В., Яхно Н. Н. Особенности когнитивных функций у пациентов с хронической болью в спине. Журнал невролологии и психиатрии им. С. С. Корсакова 2009;109(11):20–4.
61. Nadar M., Jasem Z., Manee F. The cognitive functions in adults with chronic pain: a comparative study. Pain Res Manag 2016;2016:5719380. DOI: 10.1155/2016/ 5719380. PMID: 28127233.
62. Campbell L., Clauw D., Keefe F. Persistent pain and depression: a biopsychosocial perspective. Biol Psychiatry 2003;54(3):399–409. DOI: 10.1016/s0006-3223(03)00545-6. PMID: 12893114.
63. Liu B., Liu J., Wang M. et al. From serotonin to neuroplasticity: evolvement of theories for major depressive disorder. Front Cell Neurosci 2017;11:305. DOI: 10.3389/fncel. 2017.00305. PMID: 29033793.
64. Santarelli L., Saxe M,. Gross C. et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003;301(5634): 805–9. DOI: 10.1126/science.1083328. PMID: 12907793.
65. Shilyansky C., Williams L., Gyurak A. et al. Effect of antidepressant treatment on cognitive impairments associated with depression: a randomised longitudinal study. Lancet Psychiatry 2016;3(5):425–35. DOI: 10.1016/s2215-0366(16)00012-2. PMID: 26995298.
66. Pehrson A., Cremers T., Betry С. et al. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters – a rat microdialysis and electrophysiology study. Eur Neuropsychopharmacol 2013;23(2):133–45. DOI: 10.1016/j. euroneuro.2012.04.006. PMID: 22612991.
67. Stahl S. Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): modifying serotonin’s downstream effects on glutamate and GABA (gamma amino butyric acid) release. CNS Spectrums 2015:20(4);331–6. DOI: 10.1017/ S1092852915000334. PMID: 26062900.
68. Sanchez C., Asin K., Artigas F. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther 2015; 145:43–57. DOI: 10.1016/j.pharmthera. 2014.07.001. PMID: 25016186.
Для цитирования:
Латышева Н.В., Филатова Е.Г., Осипова Д.В. Хроническая боль, депрессия и когнитивные нарушения: тесные взаимосвязи. Нервно-мышечные болезни. 2018;8(3):34-42. https://doi.org/10.17650/2222-8721-2018-8-3-34-42
For citation:
Latysheva N.V., Filatova E.G., Osipova D.V. Chronic pain, depression and cognitive impairment: a close relationship. Neuromuscular Diseases. 2018;8(3):34-42. (In Russ.) https://doi.org/10.17650/2222-8721-2018-8-3-34-42