Хроническая боль, депрессия и когнитивные нарушения: тесные взаимосвязи
Аннотация
Более половины пациентов с хронической болью (ХБ) предъявляют жалобы на когнитивные нарушения (КН), которые cнижают их трудоспособность и качество жизни. В статье представлен обзор исследований, продемонстрировавших объективные нарушения памяти, внимания, скорости мышления и исполнительной функции при ХБ. Также обсуждаются общие механизмы патогенеза КН и ХБ: нейропластичность в общих зонах головного мозга, нейромедиаторные и другие молекулярные механизмы. Представлен обзор общих патогенетических механизмов депрессии, ХБ и КН. Также приведено сравнение различных антидепрессантов в коррекции КН при депрессии и ХБ.
Об авторах
Н. В. Латышева
ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России; Клиника головной боли и вегетативных расстройств им. акад. Александра Вейна.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
125130 Москва, Старопетровский проезд, 10б.
Е. Г. Филатова
ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России; Клиника головной боли и вегетативных расстройств им. акад. Александра Вейна.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2;
125130 Москва, Старопетровский проезд, 10б.
Д. В. Осипова
ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2.
Россия
119991 Москва, ул. Трубецкая, 8, стр. 2.
Список литературы
1. Prefontaine K., Rochette A. A literature review on chronic pain: the daily overcoming of a complex problem. Br J Occupat Ther 2013;76(6):280–6. DOI: 10.4276/030802213x13706169932905.
2. Breivik H., Collett B., Ventafridda V. et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 2006;10(4):287–333. DOI: 10.1016/j.ejpain.2005.06.009. PMID: 16095934.
3. Landrø N., Fors E., Våpenstad L. et al. The extent of neurocognitive dysfunction in a multidisciplinary pain centre population. Is there a relation between reported and tested neuropsychological functioning? Pain 2013;154(7):972–7. DOI: 10.1016/j.pain.2013.01.013. PMID: 23473784.
4. Mazza S., Frot M., Rey A. A comprehensive literature review of chronic pain and memory. Prog Neuropsychophar macol Biol Psychiatry 2017;87(Pt B): 183–92. DOI: 10.1016/j.pnpbp.2017.08.006. PMID: 28797640.
5. Morone N., Abebe K., Morrow L. et al. Pain and decreased cognitive function negatively impact physical functioning in older adults with knee osteoarthritis. Pain Med 2014;15(9):1481–7. DOI: 10.1111/pme.12483. PMID: 25040845.
6. Bell T., Trost Z., Buelow M. et al. Meta-analysis of cognitive performance in fibromyalgia. J Clin Exp Neuropsychol 2018;40(7):698–714. DOI: 10.1080/13803395.2017.1422699. PMID: 29388512.
7. Bertolucci P., de Oliveira F. Cognitive impairment in fibromyalgia. Curr Pain Headache Rep 2013;17(7):344. DOI: 10.1007/s11916-013-0344-9. PMID: 23709236.
8. Tesio V., Torta D., Colonna F. et al. Are fibromyalgia patients cognitively impaired? Objective and subjective neuropsychological evidence. Arthritis Care Res (Hoboken) 2015;67(1):143–50. DOI: 10.1002/acr.22403. PMID: 25047247.
9. Berryman C., Stanton T. R., Bowering J. et al. Evidence for working memory deficits in chronic pain: a systematic review and meta-analysis. Pain 2013;154(8):1181–96. DOI: 10.1016/j.pain.2013.03.002. PMID: 23707355.
10. Moriarty O., Ruane N., O’Gorman D. et al. Cognitive impairment in patients with chronic neuropathic or radicular pain: an interaction of pain and age. Front Behav Neurosci 2017;11:100. DOI: 10.3389/fnbeh.2017.00100. PMID: 28659771.
11. Apkarian A., Sosa Y., Krauss B. et al. Chronic pain patients are impaired on an emotional decision-making task. Pain 2004;108(1–2):129–36. DOI: 10.1016/j.pain.2003.12.015. PMID: 15109516.
12. Baker K., Gibson S., GeorgiouKaristianis N. et al. Everyday executive functioning in chronic pain: specific deficits in working memory and emotion control, predicted by mood, medications, and pain interference. Clin J Pain 2016;32(8):673–80. DOI: 10.1097/AJP. 0000000000000313. PMID: 26626294.
13. Ferreira K., Oliver G., Thomaz D. et al. Cognitive deficits in chronic pain patients, in a brief screening test, are independent of comorbidities and medication use. Arq Neuropsiquiatr 2016;74(5):361–6. DOI: 10.1590/0004-282X20160071. PMID: 27191230
14. Латышева Н. В., Филатова Е. Г., Осипова Д. В. Нарушения памяти и внимания у пациентов с хронической мигренью. Нервно-мышечные болезни 2018;8(2):10–6.
15. Leavitt F., Katz R. Speed of mental operations in fibromyalgia: a selective naming speed deficit. J Clin Rheumatol 2008;14(4):214–8. DOI: 0.1097/rhu. 0b013e31817a2472. PMID: 18636019.
16. Veldhuijzen D., van Wijck A., Wille F. et al. Effect of chronic nonmalignant pain on highway driving performance. Pain 2006;122(1–2):28–35. DOI: 10.1016/j.pain.2005.12.019. PMID: 16495013.
17. Eccleston C. Chronic pain and attention: a cognitive approach. Br J Clin Psychol 1994;33(Pt 4):535–47. DOI: 10.1111/j.2044-8260.1994.tb01150.x. PMID: 7874045.
18. Baliki M., Schnitzer T., Bauer W., Apkarian A. V. Brain morphological signatures for chronic pain. PLoS One 2011;6(10):e26010. DOI: 10.1371/ journal.pone.0026010. PMID: 22022493
19. Apkarian A., Sosa Y., Sonty S. et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 2004;24(46); 10410–5. DOI: 10.1523/JNEUROSCI. 2541–04.2004. PMID: 15548656.
20. Moriarty O., McGuire B., Finn D. The effect of pain on cognitive function: a review of clinical and preclinical research. Prog Neurobiol 2011;93(3):385–404. DOI: 10.1016/j.pneurobio.2011.01.002. PMID: 21216272.
21. Luerding R., Weigand T., Bogdahn U. et al. Working memory performance is correlated with local brain morphology in the medial frontal and anterior cingulate cortex in fibromyalgia patients: structural correlates of pain-cognition interaction. Brain 2008;131(Pt 12):3222–31. DOI: 10.1093/brain/awn229. PMID: 18819988.
22. Foti M., Lo Buono V., Corallo F. et al. Neuropsychological assessment in migraine patients: a descriptive review on cognitive implications. Neurol Sci 2017;38(4):553–62. DOI: 10.1007/s10072-017-2814-z. PMID: 28101762.
23. Baliki M., Petre B., Torbey S. et al. Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci 2012;15(8):1117–9. DOI: 10.1038/nn.3153. PMID: 22751038.
24. Fallon N., Chiu Y., Nurmikko T., Stancak A. Functional connectivity with the default mode network is altered in fibromyalgia patients. PLoS One 2016;11(7):e0159198. DOI: 10.1371/ journal.pone.0159198. PMID: 27442504.
25. Grilli M. Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies. J Pain Res 2017;10:2281–6. DOI: 10.2147/JPR.S146399. PMID: 29033604.
26. Vachon-Presseau E., Tétreault P., Petre B. et al. Corticolimbic anatomical characteristics predetermine risk for chronic pain. Brain 2016;139(Pt 7):1958–70. DOI: 10.1093/brain/aww100. PMID: 27190016.
27. Barthas F., Sellmeijer J., Hugel S. et al. The anterior cingulate cortex is a critical hub for pain-induced depression. Biol Psychiatry 2015;77(3):236–45. DOI: 10.1016/j.biopsych.2014.08.004. PMID: 25433903.
28. Ebert D., Ebmeier K. The role of the cingulate gyrus in depression: from functional anatomy to neurochemistry. Biol Psychiatry 1996;39(12):1044–50. DOI: 10.1016/0006-3223(95)00320-7. PMID: 8780840.
29. Salzman C., Fusi S. Emotion, cognition, and mental state representation in amygdala and prefrontal cortex. Annu Rev Neurosci 2010;33:173–202. DOI: 10.1146/annurev.neuro. 051508.135256. PMID: 20331363.
30. Nekovarova T., Yamamotova A., Vales K. et al. Common mechanisms of pain and depression: are antidepressants also analgesics? Frontiers in Behavioral Neurosci 2014;8:99. DOI: 10.3389/fnbeh.2014.00099. PMID: 24723864.
31. Bai Y., Chiou W., Su T. et al. Proinflammatory cytokine associated with somatic and pain symptoms in depression. J Affect Disord 2014;155:28–34. DOI: 10.1016/j.jad.2013.10.019. PMID: 24176538.
32. Uçeyler N., Valenza R., Stock M. et al. Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. Arthritis Rheum 2006;54(8):2656–64. DOI: 10.1002/art.22026. PMID: 16871547.
33. Cowen P., Sherwood A. The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. J Psychopharmacol 2013;27(7):575–83. DOI: 10.1177/0269881113482531. PMID: 23535352.
34. Baune B., Brignone M., Larsen K. A network meta-analysis comparing effects of various antidepressant classes on the digit symbol substitution test(DSST) as a measure of cognitive dysfunction in patients with major depressive disorder. Int J Neuropsychopharmacol 2018;21(2): 97–107. DOI: 10.1093/ijnp/pyx070. PMID: 29053849.
35. Naser P., Kuner R. Molecular, cellular and circuit basis of cholinergic modulation of pain. Neurosci 2018;387:135–48. DOI: 10.1016/j.neuroscience. 2017.08.049. PMID: 28890048.
36. Aurora S., Brin M. F. Chronic migraine: an update on physiology, imaging, and the mechanism of action of two available pharmacologic therapies. Headache 2017;57(1):109–25. DOI: 10.1111/head.12999. PMID: 27910097.
37. Mainero C., Boshyan J., Hadjikhani N. Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine. Ann Neurol 2011;70(5):838–45. DOI: 10.1002/ana.22537. PMID: 22162064.
38. Kim J., Suh S., Seol H. et al. Regional grey matter changes in patients with migraine: a voxel-based morphometry study. Cephalalgia 2008;28(6):598–604. DOI: 10.1111/j.1468-2982.2008.01550.x. PMID: 18422725.
39. Riederer F., Marti M., Luechinger R. et al. Grey matter changes associated with medication-overuse headache: correlations with disease related disability and anxiety. World J Biol Psychiatry 2012:13(7):517–25. DOI: 10.3109/15622975.2012.665175. PMID: 22746999.
40. Lai T., Wang S. Neuroimaging findings in patients with medication overuse headache. Curr Pain Headache Rep 2018;22(1):1. DOI: 10.1007/ s11916-018-0661-0. PMID: 29340793.
41. Biagianti B., Grazzi L., Gambini O. et al. Decision-making deficit in chronic migraine patients with medication overuse. Neurol Sci 2012;33 Suppl 1: S151–5. DOI: 10.1007/s10072-012-1071-4. PMID: 22644192.
42. Gwilym S., Filippini N., Douaud G. et al. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum. 2010;62(10):2930–40. DOI: 10.1002/ art.27585. PMID: 20518076.
43. Головачева В. А., Парфенов В. А., Головачева А. А. Когнитивные жалобы и нарушения у пациентов с хронической ежедневной головной болью. Неврология, нейропсихиатрия, психосоматика 2017;9(4):55–9.
44. Costa A., Sansalone A., Squillace A. et al. Self-referred cognitive impairment in migraine patients. J Headache Pain 2015;16:A149. DOI: 10.1186/1129-2377-16-S1-A149. PMID: 28132239.
45. Lai T., Protsenko E., Cheng Y. et al. Neural plasticity in common forms of chronic headaches. Neural Plast 2015;2015:205985. DOI: 10.1155/2015/ 205985. PMID: 26366304.
46. Fumal A., Laureys S., Di Clemente L. et al. Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain 2006:129(2);543–50. DOI: 10.1093/brain/ awh691. PMID: 16330505.
47. Lam R., Kennedy S., Mclntyre R. et al. Cognitive dysfunction in major depressive disorder: effects on psychosocial functioning and implications for treatment. Can J Psychiatry 2014;59(12):649–54. DOI: 10.1177/070674371405901206. PMID: 25702365.
48. McIntyre R., Soczynska J., Woldeyohannes H. et al. The impact of cognitive impairment on perceived workforce performance: results from the International Mood Disorders Collaborative Project. Compr Psychiatry 2015;56:279–82. DOI: 10.1016/j.comppsych.2014.08.051. PMID: 25439523.
49. Carvalho A., Miskowiak K., Hyphantis T. et al. Cognitive dysfunction in depression – pathophysiology and novel targets. CNS Neurol Disord Drug Targets 2014;13(10):1819–35. DOI: 10.2174/1871527313666141130203627. PMID: 25470397.
50. Yamamoto T., Shimada H. Cognitive dysfunctions after recovery from major depressive episodes. Appl Neuropsychol Adult 2012;19(3):183–91. DOI: 10.1080/09084282.2011.643959. PMID: 23373604.
51. McKinnon M., Yucel K., Nazarov A. et al. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 2009;34(1):41–54. PMID: 19125212.
52. Videbech P., Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004;161(11):1957–66. DOI: 10.1176/ appi.ajp.161.11.1957. PMID: 15514393.
53. Arnone D., McIntosh A., Ebmeier K. et al. Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses. Eur Neuropsychopharmacol 2012;22(1):1–16. DOI: 10.1016/j.euroneuro.2011.05.003. PMID: 21723712.
54. Gao Y., Huang C., Zhao K. et al. Depression as a risk factor for dementia and mild cognitive impairment: a metaanalysis of longitudinal studies. Int J Geriatr Psychiatry 2013;28(5):441–9. DOI: 10.1002/gps.3845. PMID: 22815126.
55. Gould E., McEwen B., Tanapat P. et al. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997;17(7):2492–8. DOI: 10.1523/jneurosci.17-07- 02492.1997. PMID: 9065509.
56. Dias-Ferreira E., Sousa J., Melo I. et al. Chronic stress causes frontostriatal reorganization and affects decisionmaking. Science 2009;325(5940):621–5. DOI: 10.1126/science.1171203. PMID: 19644122.
57. Heiser P, Lanquillon S, Krieg J. Differential modulation of cytokine production in major depressive disorder by cortisol and dexamethasone. Eur Neuropsychopharmacol 2008;18(12):860–70. DOI: 10.1016/j.euroneuro.2008.07.003. PMID: 18775652.
58. Young A. H. The effects of HPA axis function on cognition and its implications for the pathophysiology of bipolar disorder. Harv Rev Psychiatry 2014; 22(6):331–3. DOI: 10.1097/HRP. 0000000000000020. PMID: 25377604.
59. Dick B., Eccleston C., Crombez G. Attentional functioning in fibromyalgia, rheumatoid arthritis, and musculoskeletal pain patients. Arthritis Rheum 2002;47(6):639–44. DOI: 10.1002/art. 10800. PMID: 12522838
60. Мелкумова К. А., Подчуфарова Е. В., Яхно Н. Н. Особенности когнитивных функций у пациентов с хронической болью в спине. Журнал невролологии и психиатрии им. С. С. Корсакова 2009;109(11):20–4.
61. Nadar M., Jasem Z., Manee F. The cognitive functions in adults with chronic pain: a comparative study. Pain Res Manag 2016;2016:5719380. DOI: 10.1155/2016/ 5719380. PMID: 28127233.
62. Campbell L., Clauw D., Keefe F. Persistent pain and depression: a biopsychosocial perspective. Biol Psychiatry 2003;54(3):399–409. DOI: 10.1016/s0006-3223(03)00545-6. PMID: 12893114.
63. Liu B., Liu J., Wang M. et al. From serotonin to neuroplasticity: evolvement of theories for major depressive disorder. Front Cell Neurosci 2017;11:305. DOI: 10.3389/fncel. 2017.00305. PMID: 29033793.
64. Santarelli L., Saxe M,. Gross C. et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003;301(5634): 805–9. DOI: 10.1126/science.1083328. PMID: 12907793.
65. Shilyansky C., Williams L., Gyurak A. et al. Effect of antidepressant treatment on cognitive impairments associated with depression: a randomised longitudinal study. Lancet Psychiatry 2016;3(5):425–35. DOI: 10.1016/s2215-0366(16)00012-2. PMID: 26995298.
66. Pehrson A., Cremers T., Betry С. et al. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters – a rat microdialysis and electrophysiology study. Eur Neuropsychopharmacol 2013;23(2):133–45. DOI: 10.1016/j. euroneuro.2012.04.006. PMID: 22612991.
67. Stahl S. Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): modifying serotonin’s downstream effects on glutamate and GABA (gamma amino butyric acid) release. CNS Spectrums 2015:20(4);331–6. DOI: 10.1017/ S1092852915000334. PMID: 26062900.
68. Sanchez C., Asin K., Artigas F. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther 2015; 145:43–57. DOI: 10.1016/j.pharmthera. 2014.07.001. PMID: 25016186.
Для цитирования:
Латышева Н.В., Филатова Е.Г., Осипова Д.В. Хроническая боль, депрессия и когнитивные нарушения: тесные взаимосвязи. Нервно-мышечные болезни. 2018;8(3):34-42. https://doi.org/10.17650/2222-8721-2018-8-3-34-42
For citation:
Latysheva N.V., Filatova E.G., Osipova D.V. Chronic pain, depression and cognitive impairment: a close relationship. Neuromuscular Diseases. 2018;8(3):34-42. (In Russ.) https://doi.org/10.17650/2222-8721-2018-8-3-34-42
Просмотров: 208
Послать статью по эл. почте 