Steroid myopathy in patients with myasthenia gravis: a literature review

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Abstract

Steroid myopathy is a common drug-induced non-inflammatory myopathy that affects patients requiring long-term glucocorticoid treatment for various autoimmune, inflammatory and oncological diseases. According to the neurology clinical practice guidelines, non-fluorinated glucocorticoids are the first-line pathogen-directed therapy for a number of dysimmune neuromuscular disorders, including myasthenia gravis. Long-term high-dose steroid treatment regime for myasthenia gravis leads to both acute and chronic development of glucocorticoids-induced proximal muscle weakness and atrophy. Steroid myopathy, along with other undesirable side effects of glucocorticoids therapy, impact health-related quality of life, patient satisfaction and adherence to treatment. Hence, further studies are required to expand our knowledge of clinical evaluation, diagnostic testing and prevention approaches for glucocorticoids-induced myopathy. The aim of this literature review is to analyze existing data on pathogenesis, diagnostic tools and treatment strategies for steroid myopathy.

About the authors

S. A. Zaytsevskaya

Research Center of Neurology

Author for correspondence.
Email: sona-zait@mail.ru
ORCID iD: 0000-0001-6889-5363

Sofya Aleksandrovna

80 Volokolamskoe Shosse, Moscow 125367

Russian Federation

N. A. Suponeva

Research Center of Neurology

Email: fake@neicon.ru
ORCID iD: 0000-0003-3956-6362

80 Volokolamskoe Shosse, Moscow 125367

Russian Federation

K. V. Antonova

Research Center of Neurology

Email: fake@neicon.ru
ORCID iD: 0000-0003-2373-2231

80 Volokolamskoe Shosse, Moscow 125367

Russian Federation

D. A. Grishina

Research Center of Neurology

Email: fake@neicon.ru
ORCID iD: 0000-0002-7924-3405

80 Volokolamskoe Shosse, Moscow 125367

Russian Federation

A. M. Narbut

Research Center of Neurology

Email: fake@neicon.ru
ORCID iD: 0000-0003-2026-5199

80 Volokolamskoe Shosse, Moscow 125367

Russian Federation

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