Исследовательское и клиническое значение диагностической транскраниальной магнитной стимуляции у детей с черепно-мозговой травмой: обзор метода

Согласно исследованиям, транскраниальная магнитная стимуляция имеет потенциал в качестве неинвазивного прогностического метода количественной оценки нейрофизиологических изменений головного мозга после черепно-мозговой травмы (ЧМТ). В патофизиологической основе изменений параметров транскраниальной магнитной стимуляции при ЧМТ лежат нарушение регуляции высвобождения нейромедиаторов, изменение экспрессии рецепторов, повреждение интернейронов и микроцитоархитектоники, что провоцирует нарушение функционального баланса между корковым возбуждением и торможением. Особенностью детской популяции с последствиями ЧМТ оказалась уязвимость тормозных механизмов интернейронов за счет снижения уровня ГАМКB-рецепторов опосредованного коркового торможения. Целью настоящей публикации стал анализ наиболее информативных параметров диагностической транскраниальной магнитной стимуляции в детской популяции с последствиями ЧМТ на основе имеющейся литературы.

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