Email this article Case of hypokalemic paralysis due to use of drug containing therapeutic doses liquorice root
- Authors: Vasilenko A.F.1, Karpova M.I.1, Sergeitsev A.N.1, Zaliautdinova R.I.1
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Affiliations:
- South Ural State Medical University, Ministry of Health of Russian Federation
- Issue: Vol 9, No 4 (2019)
- Pages: 57-60
- Section: CLINICAL DISCUSSION
- Published: 10.01.2020
- URL: https://nmb.abvpress.ru/jour/article/view/354
- DOI: https://doi.org/10.17650/2222-8721-2019-9-4-57-60
- ID: 354
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Abstract
The administration of licorice root or licorice preparations (lat. – Glycyrrhiza glabra) is one of the rare causes of hypokalemia. The main active component of licorice is glycyrrhizic acid has mineralocorticoid-like effects. Hypokalemia caused by long-term use of glycyrrhizic acid drugs leads to the development of pseudohyperaldosteronism syndrome including arterial hypertension, metabolic alkalosis and muscle weakness. In this publication we present the clinical case of severe hypokalemia due to use of the drug “Phosphogliv”, containing the trisodium salt of glycyrrhizic acid as one of the active substances. The specific feature of the case given is that the complication was caused using the therapeutic dosage of the drug.
About the authors
A. F. Vasilenko
South Ural State Medical University, Ministry of Health of Russian Federation
Email: fake@neicon.ru
ORCID iD: 0000-0001-5799-7233
64 Vorovskogo St., Chelyabinsk 454092
Russian FederationM. I. Karpova
South Ural State Medical University, Ministry of Health of Russian Federation
Author for correspondence.
Email: kmi_2008@mail.ru
ORCID iD: 0000-0001-5848-7235
64 Vorovskogo St., Chelyabinsk 454092
Russian FederationA. N. Sergeitsev
South Ural State Medical University, Ministry of Health of Russian Federation
Email: fake@neicon.ru
ORCID iD: 0000-0002-2155-5799
64 Vorovskogo St., Chelyabinsk 454092
Russian FederationR. Iu. Zaliautdinova
South Ural State Medical University, Ministry of Health of Russian Federation
Email: fake@neicon.ru
ORCID iD: 0000-0002-7009-735X
64 Vorovskogo St., Chelyabinsk 454092
Russian FederationReferences
- Keizer N.P., Zharskiy S.L., Bogatkov S.D. et al. The case of hypokalemia and rhabdomyolysis in chronic licorice ingestion. Dal’nevostonyj medicinskij zhurnal = Far Eastern Medical Journal 2015;5:78–81. (In Russ.)
- Suponeva N.A., Piradov M.A., Nikitin S.S. et al. Acute hypokalemic paralysis due to an overdose of a drug containing licorice root. Annaly klinicheskoj i eksperimental’noj nevrologii = Annals of Clinical and Experimental Neurology 2008;2(1):47–50. (In Russ.)
- Meltem A.C., Figen C., Nalan M.A. et al. A hypokalemic muscular weakness after licorice ingestion: a case report. Cases J 2009;2:8053. doi: 10.1186/1757-1626-0002-0000008053. PMID: 20181204.
- Peninkilampi R., Eslick E.M., Eslick G.D. The association between consistent licorice ingestion, hypertension and hypokalemia: a systematic review and meta-analysis. J Hum Hypertens 2017: 31(11):1–9. doi: 10.1038/jhh.2017.45. PMID: 28660884.
- Cherniavskii V.V., Sizenko A.K., Gvozdetskaia L.S. Inflammation in chronic liver diseases and possible approaches to treatment. Gastroenterology = Gastroenterologia 2014;1(51):111–6. (In Russ.)
- Food, U.S. GRAS status of licorice (Glycyrrhiza), ammoniated glycyrrhizin and monoammonium glycyrrhizinate. Federal Register 1985:5099.
- Kirusu S., Inoue I., Kawagoe T. et al. Clinical profile of patients with symptomatic glycyrrhizin-induced hypokalemia. Letters to the editor 2008;56:1579–80. doi: 10.1111/j.1532-5415.2008.01781.x. PMID: 18808610.
- Nazari S., Rameshrad M., Hosseinzadeh H. Toxicological effects of Glycyrrhiza glabra (Licorice): a review toxic effect. Phytother Res 2017;31:1635–50. doi: 10.1002/ptr.5893. PMID: 28833680.
- Suponeva N.A., Nikitin S.S., Piradov M.A. Examination of the patient, differential diagnosis and the most frequent causes of acute flaccid quadriparesis. Nervno-myshechnye bolezni = Neuromuscular Diseases 2011;1:5–13. (In Russ.)
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