Clinical features of fatigue in amyotrophic lateral sclerosis
https://doi.org/10.17650/2222-8721-2025-15-1-10-17
Abstract
Background. Fatigue (athenia) is widely spread among patients with neurological disorders. It substantially reduces patients’ quality of life. Its clinical features and mechanisms of the development have not been studies sufficiently.
Aim. To analyze clinical features of fatigue in patients with amyotrophic lateral sclerosis.
Materials and methods. Forty two patients with amyotrophic lateral sclerosis were recruited to the study. Fatigue was assessed using the Multidimensional Fatigue Inventory (MFI-20). The independent predictors of the severity of fatigue were calculated using linear regression analysis.
Results. Fatigue was detected in 27 (64 %) patients. The most common type of fatigue was reduced activity, the least common – general fatigue. Severity of depression and motor neurological deficit were independent predictors of fatigue according to general MFI-20 score.
Conclusion. Fatigue in amyotrophic lateral sclerosis is wide spread phenomenon. Its clinical features include both physical and mental components.
Supporting agencies: This work was supported by the Bashkir State Medical University Strategic Academic Leadership Program (“PRIORITY-2030”).
About the Authors
E. V. Pervushina
Bashkir State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
3 Lenina St., Ufa 450008
M. A. Kutlubaev
Bashkir State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
3 Lenina St., Ufa 450008
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For citations:
Pervushina E.V., Kutlubaev M.A. Clinical features of fatigue in amyotrophic lateral sclerosis. Neuromuscular Diseases. 2025;15(1):10-17. (In Russ.) https://doi.org/10.17650/2222-8721-2025-15-1-10-17
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