Иммуноглобулины в неврологической практике: обзор литературы
https://doi.org/10.17650/2222-8721-2019-9-1-32-51
Аннотация
Сегодня высокодозная терапия иммуноглобулинами человека получает все большее распространение в лечении болезней нервной системы. Эффективность и безопасность использования иммуноглобулинов доказана в рандомизированных контролируемых исследованиях у пациентов с хронической воспалительной демиелинизирующей полинейропатией, синдромом Гийена–Барре, мультифокальной моторной нейропатией, что отражено в систематических обзорах. Обсуждаются вопросы о дозах, интервалах и продолжительности лечения и необходимости повторных инфузий при этих состояниях. Использование высокодозной терапии иммуноглобулинами является опцией при миастенических кризах и обострениях миастении гравис, синдроме ригидного человека, а также терапией 2-й линии при дерматомиозите и в некоторых случаях при полимиозите. Применение иммуноглобулинов при рассеянном склерозе, миозите с включениями, резистентной эпилепсии остается не до конца обоснованной. В обзоре обсуждается эффективность высокодозной терапии иммуноглобулинами в неврологии на основании информативных исследований, с учетом основных критериев выбора препарата для адекватной внутривенной иммунотерапии.
Об авторах
C. С. НикитинРоссия
117258 Москва, ул. Кржижановского, 17/2,
117478 Москва, Каширское шоссе, 24/15
Л. М. Борискина
Россия
Лидия Михайловна Борискина
117478 Москва, Каширское шоссе, 24/15,
101000 Москва, ул. Мясницкая, 13/13
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Рецензия
Для цитирования:
Никитин C.С., Борискина Л.М. Иммуноглобулины в неврологической практике: обзор литературы. Нервно-мышечные болезни. 2019;9(1):32-51. https://doi.org/10.17650/2222-8721-2019-9-1-32-51
For citation:
Nikitin S.S., Boriskina L.M. Immunoglobulins in neurological practice: a review of the literature. Neuromuscular Diseases. 2019;9(1):32-51. (In Russ.) https://doi.org/10.17650/2222-8721-2019-9-1-32-51