The use of rituximab in the treatment of disimmune polyneuropathy: a description of clinical cases and a literature review
https://doi.org/10.17650/2222-8721-2019-9-2-50-58
Abstract
Dysimmune neuropathies are heterogeneous group of acquired immune-mediated diseases, accompanied by damage to the peripheral nervous system. As a standard therapy, prednisolone and intravenous immunoglobulins are used. Also encouraging efficacy is demonstrated by the use of a genetically engineered chimeric monoclonal antibody to the CD20 antigen found on the surface of normal and malignant B-cells – rituximab. Rituximab shows encouraging results. We reviewed the use of rituximab for dysimmune polyneuropathies and described our experience in administration of Lewis–Sumner syndrome and myelin-associated glycoprotein related neuropathy with rituximab.
About the Authors
V. N. Kiselev
Russian national Center for Emergency and Radiation Medicine n. a. A. M. Nikiforova
Russian Federation
54 Optikov St., Saint-Peterburg 197374, Russia
Russian Federation
54 Optikov St., Saint-Peterburg 197374, Russia
V. G. Potapenko
City Clinical Hospital № 31
Russian Federation
3 Dinamo Prospect, Saint-Peterburg 197110, Russia
Russian Federation
3 Dinamo Prospect, Saint-Peterburg 197110, Russia
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Review
For citations:
Kiselev V.N., Potapenko V.G. The use of rituximab in the treatment of disimmune polyneuropathy: a description of clinical cases and a literature review. Neuromuscular Diseases. 2019;9(2):50-58. (In Russ.) https://doi.org/10.17650/2222-8721-2019-9-2-50-58
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