Современное представление о химиоиндуцированной полинейропатии (обзор литературы)
https://doi.org/10.17650/2222-8721-2023-13-1-10-21
Аннотация
Обзор посвящен химиоиндуцированной полинейропатии – частому нежелательному явлению терапии злокачественных новообразований, которое снижает качество жизни пациентов и может приводить к изменению тактики ведения: модификации дозы, отсрочке введения препарата и даже полному прекращению лечения, что ставит под угрозу жизнь пациента. В основе химиоиндуцированного повреждающего действия периферических нервов лежат разные механизмы в зависимости от вида цитотоксического агента. Наиболее нейротоксичными являются препараты платины, таксаны, алкалоиды барвинка, бортезомиб и талидомид. В результате нейротоксического воздействия возникает повреждение тонких и толстых волокон периферических нервов. Однако до сих пор остается загадкой, почему у одного пациента развиваются проявления нейротоксичности, а у другого – нет. Перед современным медицинским сообществом по-прежнему остро стоит вопрос изучения механизмов развития, факторов риска, а также поиска биомаркеров и разработки методов профилактики, лечения химиоиндуцированной полинейропатии. Обобщены результаты исследований по механизму возникновения, клинике, диагностике, профилактике и лечению химиоиндуцированных полинейропатий.
Ключевые слова
При поддержке: Авторы благодарят руководство ФГАОУ ВО «Балтийский федеральный университет им. Иммануила Канта» за оказанную поддержку.
Об авторах
О. А. Тихонова
ФГАОУ ВО «Балтийский федеральный университет им. Иммануила Канта»
Россия
Россия
Ольга Алексеевна Тихонова,
236016 Калининград, ул. Александра Невского, 14
Д. С. Дружинин
ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России
Россия
Россия
150000 Ярославль, ул. Революционная, 5
А. М. Тынтерова
ФГАОУ ВО «Балтийский федеральный университет им. Иммануила Канта»
Россия
Россия
236016 Калининград, ул. Александра Невского, 14
И. В. Реверчук
ФГАОУ ВО «Балтийский федеральный университет им. Иммануила Канта»
Россия
Россия
236016 Калининград, ул. Александра Невского, 14
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Рецензия
Для цитирования:
Тихонова О.А., Дружинин Д.С., Тынтерова А.М., Реверчук И.В. Современное представление о химиоиндуцированной полинейропатии (обзор литературы). Нервно-мышечные болезни. 2023;13(1):10-21. https://doi.org/10.17650/2222-8721-2023-13-1-10-21
For citation:
Tikhonova O.A., Druzhinin D.S., Tynterova A.M., Reverchuk I.V. Current understanding of chemotherapy-induced peripheral neuropathy (literature review). Neuromuscular Diseases. 2023;13(1):10-21. (In Russ.) https://doi.org/10.17650/2222-8721-2023-13-1-10-21
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